EFINOPEGDUTIDE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Investigational

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 23:16:51 GMT 2025` Edited by `admin` on `Tue Apr 01 23:16:51 GMT 2025`
Protein Type	FC FUSION PROTEIN
Protein Sub Type	IGG4
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	DR6P1M58PO
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

HM-12525A

Preferred Name

English

EFINOPEGDUTIDE

Official Name

English

JNJ-64565111

Code

English

POLY(OXY-1,2-ETHANEDIYL), .ALPHA.-HYDRO-.OMEGA.-HYDROXY-, .ALPHA.30-ETHER WITH-L-HISTIDYL-2-METHYLALANYL-L-GLUTAMINYLGLYCYL-L-THREONYL-L-PHENYLALANYL-L-THREONYL-L-SERYL-L-.ALPHA.-ASPARTYL-L-TYROSYL-L-SERYL-L-LYSYL-L-TYROSYL-L-LEUCYL-L-.ALPHA.-ASPARTYL-L-

Common Name

English

LAPS-GLP/GCG

Common Name

English

OXYNTOMODULIN ANALOGUE, CONJUGATED BY A 10KDA POLYETHYLENE GLYCOL (PEG) LINKER (N ~ 225) TO AN FC PORTION DIMER OF HUMAN IMMUNOGLOBULIN G4 (IGG4): N1.9-(3-(.OMEGA.-(3-(3-((3RS)-3-((16'',20''-ANHYDRO-(S2''>B, S16''>E, R17''>K, Q20''>K, D21''>E, K30''>C)-H

Common Name

English

HM12525A

Code

English

EFINOPEGDUTIDE [USAN]

Common Name

English

efinopegdutide [INN]

Common Name

English

Code System Code Type Description

SMS_ID

100000181757

Created by admin on Tue Apr 01 23:16:51 GMT 2025 , Edited by admin on Tue Apr 01 23:16:51 GMT 2025

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INN

10793

Created by admin on Tue Apr 01 23:16:51 GMT 2025 , Edited by admin on Tue Apr 01 23:16:51 GMT 2025

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NCI_THESAURUS

C169932

Created by admin on Tue Apr 01 23:16:51 GMT 2025 , Edited by admin on Tue Apr 01 23:16:51 GMT 2025

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USAN

GH-23

Created by admin on Tue Apr 01 23:16:51 GMT 2025 , Edited by admin on Tue Apr 01 23:16:51 GMT 2025

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DRUG BANK

DB15077

Created by admin on Tue Apr 01 23:16:51 GMT 2025 , Edited by admin on Tue Apr 01 23:16:51 GMT 2025

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CAS

2055640-93-0

Created by admin on Tue Apr 01 23:16:51 GMT 2025 , Edited by admin on Tue Apr 01 23:16:51 GMT 2025

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FDA UNII

DR6P1M58PO

Created by admin on Tue Apr 01 23:16:51 GMT 2025 , Edited by admin on Tue Apr 01 23:16:51 GMT 2025

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From	To
1_3	2_3
1_35	1_95
1_141	1_199
2_35	2_95
2_141	2_199

Linkage Type	Residue Index
AMIDE BOND	3_16	3_20

Related Record Type Details


					EF38T7N5MI

GLUCAGON-LIKE PEPTIDE 1 RECEPTOR

TARGET -> AGONIST


					G2BWF9H576

GLUCAGON RECEPTOR

TARGET -> AGONIST

Related Record Type Details


					DR6P1M58PO

ACTIVE MOIETY

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[3_30]	C-TERMINUS			PROLYL PEG-230 CYSTEINE LINKER	OW3Z3MHO4K
AMINO_ACID_SUBSTITUTION	[3_16] [3_20]	SITE_SPECIFIC			N<sup>6</sup>-L-?-Glutamyl-L-lysine	O19B8F457C
AMINO_ACID_SUBSTITUTION	[3_2]	SITE_SPECIFIC			.ALPHA.-AMINOISOBUTYRIC ACID	1E7ZW41IQU
AMINO_ACID_SUBSTITUTION	[1_1]	N-TERMINUS			PROLYL PEG-230 CYSTEINE LINKER	OW3Z3MHO4K

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL