Givilmeran

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NCATS

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Wed Apr 02 20:20:57 GMT 2025` Edited by `admin` on `Wed Apr 02 20:20:57 GMT 2025`
Nucleic Acid Type	mRNA VACCINE
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	DQ7W4DRD5W
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Givilmeran

Official Name

English

CX-035784

Preferred Name

English

messenger RNA (mRNA), 5' capped, encoding codon-optimised human methylmalonyl-coenzyme A mutase (MMUT, MUT, MCM) flanked by 5' and 3' untranslated regions (UTRs) followed by a 3' polyadenylation (polyA) tail and concluded by a 5-nucleotide XbaI scar. The

Common Name

English

RNA (recombinant 5?-(m7G-(5??5?)-ppp-Gm)-capped all uridine?N1-methylpseudouridine-substituted 5?-untranslated region plus human methylmalonyl-coenzyme A mutase plus 3?-untranslated region-containing microRNA-142 binding sites plus poly(A)-tailed messeng

Common Name

English

givilmeran [INN]

Common Name

English

Code System Code Type Description

CAS

2924731-69-9

Created by admin on Wed Apr 02 20:20:57 GMT 2025 , Edited by admin on Wed Apr 02 20:20:57 GMT 2025

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SMS_ID

300000056803

Created by admin on Wed Apr 02 20:20:57 GMT 2025 , Edited by admin on Wed Apr 02 20:20:57 GMT 2025

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NCI_THESAURUS

C213397

Created by admin on Wed Apr 02 20:20:57 GMT 2025 , Edited by admin on Wed Apr 02 20:20:57 GMT 2025

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INN

13150

Created by admin on Wed Apr 02 20:20:57 GMT 2025 , Edited by admin on Wed Apr 02 20:20:57 GMT 2025

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FDA UNII

DQ7W4DRD5W

Created by admin on Wed Apr 02 20:20:57 GMT 2025 , Edited by admin on Wed Apr 02 20:20:57 GMT 2025

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Sugar	Site Range	Site Count
D-Ribose (RNA)	1_1-1_2674	2674 / 2674

Linkage	Site Range	Site Count
Phosphate	1_2-1_2674	2673 / 2673

Related Record Type Details


					47VA6JGH79

METHYLMALONYL-COA MUTASE, MITOCHONDRIAL

TARGET->ENZYME REPLACEMENT

Amount:


					47VA6JGH79

METHYLMALONYL-COA MUTASE, MITOCHONDRIAL

EXPRESSED PROTEIN->VECTOR

Amount:

Related Record Type Details


					DQ7W4DRD5W

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOSIDE_SUBSTITUTION		RESIDUE_SPECIFIC	U		N1-METHYLPSEUDOURIDINE	09RAD4M6WF
NUCLEOTIDE SUBSTITUTION	[1_1]	5'-TERMINUS			5'-GUANOSINE-M-RNA-CAP-1-3'-PHOSPHATE	T0HQY09X7B

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Coding region	NUCLEIC ACID FEATURE
3' untranslated region (3'-UTR)	NUCLEIC ACID FEATURE
5'-UTR	NUCLEIC ACID FEATURE
Poly (A) tail + Xbal Scar	NUCLEIC ACID FEATURE
microRNA-142 (miR-142) binding sites	NUCLEIC ACID FEATURE