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Details

Stereochemistry ABSOLUTE
Molecular Formula C13H17N2O4S2.K
Molecular Weight 368.513
Optical Activity UNSPECIFIED
Defined Stereocenters 3 / 3
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ALMECILLIN POTASSIUM

SMILES

[K+].CC1(C)S[C@@H]2[C@H](NC(=O)CSCC=C)C(=O)N2[C@H]1C([O-])=O

InChI

InChIKey=ONYTXCTVWDZLFD-GITWGATASA-M
InChI=1S/C13H18N2O4S2.K/c1-4-5-20-6-7(16)14-8-10(17)15-9(12(18)19)13(2,3)21-11(8)15;/h4,8-9,11H,1,5-6H2,2-3H3,(H,14,16)(H,18,19);/q;+1/p-1/t8-,9+,11-;/m1./s1

HIDE SMILES / InChI
Molecular Formula C13H17N2O4S2
Molecular Weight 329.415
Charge -1
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 3 / 3
E/Z Centers 0
Optical Activity UNSPECIFIED
Molecular Formula K
Molecular Weight 39.0983
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

ALMECILLIN (also known as penicillin O) is an antibiotic that can be safely substituted for penicillin G in instances of hypersensitivity reactions to the latter.

Approval Year

1950
105
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Not Provided
511
Unknown

Approved Use

Unknown
Doses

Doses

DosePopulationAdverse events​
1000000 unit 1 times / day multiple, intramuscular
Highest studied dose
Dose: 1000000 unit, 1 times / day
Route: intramuscular
Route: multiple
Dose: 1000000 unit, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/13182618
unhealthy, 23 years
Health Status: unhealthy
Age Group: 23 years
Sex: M
Sources:
https://pubmed.ncbi.nlm.nih.gov/13182618
Other AEs: Nausea, Increased salivation...
Other AEs:
Nausea (mild)
Increased salivation
Sources:
https://pubmed.ncbi.nlm.nih.gov/13182618
600000 unit single, intramuscular
Dose: 600000 unit
Route: intramuscular
Route: single
Dose: 600000 unit
Sources:
https://pubmed.ncbi.nlm.nih.gov/13182618
unhealthy, 23 years
Health Status: unhealthy
Age Group: 23 years
Sex: M
Sources:
https://pubmed.ncbi.nlm.nih.gov/13182618
Disc. AE: Anaphylactic shock...
AEs leading to
discontinuation/dose reduction:
Anaphylactic shock (severe)
Sources:
https://pubmed.ncbi.nlm.nih.gov/13182618
AEs

AEs

AESignificanceDosePopulation
Increased salivation
1000000 unit 1 times / day multiple, intramuscular
Highest studied dose
Dose: 1000000 unit, 1 times / day
Route: intramuscular
Route: multiple
Dose: 1000000 unit, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/13182618
unhealthy, 23 years
Health Status: unhealthy
Age Group: 23 years
Sex: M
Sources:
https://pubmed.ncbi.nlm.nih.gov/13182618
Nausea mild
1000000 unit 1 times / day multiple, intramuscular
Highest studied dose
Dose: 1000000 unit, 1 times / day
Route: intramuscular
Route: multiple
Dose: 1000000 unit, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/13182618
unhealthy, 23 years
Health Status: unhealthy
Age Group: 23 years
Sex: M
Sources:
https://pubmed.ncbi.nlm.nih.gov/13182618
Anaphylactic shock severe
Disc. AE
600000 unit single, intramuscular
Dose: 600000 unit
Route: intramuscular
Route: single
Dose: 600000 unit
Sources:
https://pubmed.ncbi.nlm.nih.gov/13182618
unhealthy, 23 years
Health Status: unhealthy
Age Group: 23 years
Sex: M
Sources:
https://pubmed.ncbi.nlm.nih.gov/13182618
Sourcing

Sourcing

Vendor/AggregatorIDURL
ABI Chem
AC1L2G0T
Alfa Chemistry
87-09-2
https://www.alfa-chemistry.com/cas_87-09-2.htm
ChemMol
99171458
http://www.chemmol.com/chemmol/99171458.html
ChemTik
CTK3E8703
Compound Cloud
71365
eMolecules
260188440
NovoSeek
71365
ZINC
ZINC000004214768
http://zinc15.docking.org/substances/ZINC000004214768
PubMed

PubMed

TitleDatePubMed
Studies on the mechanism of the formation of the penicillin antigen. I. Delayed allergic cross-reactions among penicillin G and its degradation products.
1960-12-01
Some immunochemical properties of penicillenic acid. An antigenic determinant derived from penicillin.
1960-12-01
Clinical and pharmacologic studies with allylmercaptomethyl penicillin (penicillin O).
1951-08
Use of penicillin O in patients hypersensitive to pencilling G.
1950-07-01
Patents

Patents

JPH0349690A
3
Substance Class Chemical
Created
by admin
on Mon Mar 31 22:53:23 GMT 2025
Edited
by admin
on Mon Mar 31 22:53:23 GMT 2025
Record UNII
DP2X0D6YBT
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PENICILLIN O POTASSIUM
Preferred Name English
ALMECILLIN POTASSIUM
Common Name English
POTASSIUM PENICILLIN O
Common Name English
PENICILLIN O POTASSIUM SALT [MI]
Common Name English
4-THIA-1-AZABICYCLO(3.2.0)HEPTANE-2-CARBOXYLIC ACID, 3,3-DIMETHYL-7-OXO-6-(((2-PROPENYLTHIO)ACETYL)AMINO)-, MONOPOTASSIUM SALT, (2S-(2.ALPHA.,5.ALPHA.,6.BETA.))-
Systematic Name English
Code System Code Type Description
CAS
897-61-0
Created by admin on Mon Mar 31 22:53:23 GMT 2025 , Edited by admin on Mon Mar 31 22:53:23 GMT 2025
PRIMARY
MERCK INDEX
m8478
Created by admin on Mon Mar 31 22:53:23 GMT 2025 , Edited by admin on Mon Mar 31 22:53:23 GMT 2025
PRIMARY Merck Index
PUBCHEM
23675011
Created by admin on Mon Mar 31 22:53:23 GMT 2025 , Edited by admin on Mon Mar 31 22:53:23 GMT 2025
PRIMARY
ChEMBL
CHEMBL2105909
Created by admin on Mon Mar 31 22:53:23 GMT 2025 , Edited by admin on Mon Mar 31 22:53:23 GMT 2025
PRIMARY
FDA UNII
DP2X0D6YBT
Created by admin on Mon Mar 31 22:53:23 GMT 2025 , Edited by admin on Mon Mar 31 22:53:23 GMT 2025
PRIMARY
EPA CompTox
DTXSID70237861
Created by admin on Mon Mar 31 22:53:23 GMT 2025 , Edited by admin on Mon Mar 31 22:53:23 GMT 2025
PRIMARY
Related Record Type Details
Structure of ALMECILLIN
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of ALMECILLIN
ACTIVE MOIETY
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