FLUPEROLONE ACETATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C24H31FO6
Molecular Weight	434.4977
Optical Activity	UNSPECIFIED
Defined Stereocenters	8 / 8
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12CC[C@](O)(C(=O)[C@H](C)OC(C)=O)[C@@]1(C)C[C@H](O)[C@@]3(F)[C@@]2([H])CCC4=CC(=O)C=C[C@]34C

InChI

InChIKey=HHPZZKDXAFJLOH-QZIXMDIESA-N

InChI=1S/C24H31FO6/c1-13(31-14(2)26)20(29)23(30)10-8-17-18-6-5-15-11-16(27)7-9-21(15,3)24(18,25)19(28)12-22(17,23)4/h7,9,11,13,17-19,28,30H,5-6,8,10,12H2,1-4H3/t13-,17-,18-,19-,21-,22-,23-,24-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C24H31FO6
Molecular Weight	434.4977
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	8 / 8
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://dtb.bmj.com/content/1/15/58 | https://www.ncbi.nlm.nih.gov/pubmed/13984971 | https://www.ncbi.nlm.nih.gov/pubmed/14209713

Fluperolone (P-1742 or Methral) is a topical fluorinated prednisolone derivative exerting an anti-inflammatory activity. It demonstrated effectivity in the treatment of various dermatoses.

Originator

Approval Year

PubMed

Title	Date	PubMed

Sample Use Guides

In Vivo Use Guide

0.1% ointment

Route of Administration: Transdermal

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:18:58 GMT 2023` Edited by `admin` on `Fri Dec 15 15:18:58 GMT 2023`
Record UNII	DOL7Q9DPF9
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FLUPEROLONE ACETATE

Official Name

English

P-1742

Code

English

9-Fluoro-11β,17α-dihydroxy-17-(S)-lactoylandrosta-1,4-dien-3-one 17β-acetate

Common Name

English

21-METHYL-9.ALPHA.-FLUOROPREDNISOLONE ACETATE

Common Name

English

ANDROSTA-1,4-DIEN-3-ONE, 17-(2-(ACETYLOXY)-1-OXOPROPYL)-9-FLUORO-11,17-DIHYDROXY-, (11.BETA.,17.ALPHA.,17(S))-

Common Name

English

ALACORTRIL

Brand Name

English

Fluperolone acetate [WHO-DD]

Common Name

English

METHRAL

Brand Name

English

FLUPEROLONE 21-ACETATE

Common Name

English

ANDROSTA-1,4-DIEN-3-ONE, 17-((2S)-2-(ACETYLOXY)-1-OXOPROPYL)-9-FLUORO-11,17-DIHYDROXY-, (11.BETA.,17.ALPHA.)-

Common Name

English

FLUPEROLONE ACETATE [MI]

Common Name

English

FLUPEROLONE ACETATE [USAN]

Common Name

English

Code System Code Type Description

EPA CompTox

DTXSID50895064