Lanerkitug

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 16:45:41 GMT 2025` Edited by `admin` on `Wed Apr 02 16:45:41 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1\|LAMDA
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	DNV66ACK7K
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Lanerkitug

Official Name

English

BAY 3375968

Preferred Name

English

BAY-3375968

Code

English

Immunoglobulin G1, anti-(human CC chemokine receptor CCR8) (human monoclonal BAY 3375968 ?1-chain), disulfide with human monoclonal BAY 3375968 ?-chain, dimer

Common Name

English

immunoglobulin G1-lambda2, anti-[Homo sapiens CCR8 (C-C motif chemokine receptor 8, CKR-L1, CDw198)], Homo sapiens monoclonal antibody

Common Name

English

lanerkitug [INN]

Common Name

English

H-gamma1 heavy chain Homo sapiens (1-452) [VH(Homo sapiens IGHV3-23*01 (92.9%) -(IGHD) -IGHJ4*01 (93.3%)) [8.8.15] (26-33.51-58.97-111) (1-122) -Homo sapiens IGHG1*01 (100%), G1m17,1 CH1 K120, CH3 D12, L14 (CH1 K120 (219) (123-220), hinge 1-15 (221-235),

Common Name

English

Code System Code Type Description

SMS_ID

300000051276

Created by admin on Wed Apr 02 16:45:41 GMT 2025 , Edited by admin on Wed Apr 02 16:45:41 GMT 2025

PRIMARY

INN

12887

Created by admin on Wed Apr 02 16:45:41 GMT 2025 , Edited by admin on Wed Apr 02 16:45:41 GMT 2025

PRIMARY

FDA UNII

DNV66ACK7K

Created by admin on Wed Apr 02 16:45:41 GMT 2025 , Edited by admin on Wed Apr 02 16:45:41 GMT 2025

PRIMARY

CAS

2839417-54-6

Created by admin on Wed Apr 02 16:45:41 GMT 2025 , Edited by admin on Wed Apr 02 16:45:41 GMT 2025

PRIMARY

NCI_THESAURUS

C192110

Created by admin on Wed Apr 02 16:45:41 GMT 2025 , Edited by admin on Wed Apr 02 16:45:41 GMT 2025

PRIMARY

From	To
1_22	1_96
2_22	2_96
2_149	2_205
2_225	4_216
2_266	2_326
1_149	1_205
2_372	2_430
3_22	3_90
3_139	3_198
4_22	4_90
4_139	4_198
1_225	3_216
1_231	2_231
1_234	2_234
1_266	1_326
1_372	1_430

Glycosylation Type

MAMMALIAN, AFUCOSYLATED

Glycosylation Link Type	Site
N	1_302
N	2_302

Related Record Type Details


					DNV66ACK7K

ACTIVE MOIETY

Comments:

BAY 3375968 is a monoclonal antibody (mAb) designed to deplete the C-C motif chemokine receptor 8 (CCR8)-positive regulatory T cells (Tregs) via antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP)

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[3_1] [4_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42
AMINO ACID REMOVAL	[1_452] [2_452]	C-TERMINUS			LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL