Mipletamig

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 05:07:46 GMT 2025` Edited by `admin` on `Wed Apr 02 05:07:46 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY AND PEPTIDE FUSION PROTEIN
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	DNP8BBW84R
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

APVO-436

Preferred Name

English

Mipletamig

Official Name

English

ANTI-CD123/CD3 BISPECIFIC ANTIBODY APVO436

Common Name

English

IG chainscFvkh-G1hCH2CH3-scFvhk Homo sapiens and humanized (1-757) [scFvkh anti-IL3RA Homo sapiens (1-259) [V-KAPPA (Homo sapiens IGKV4-1*01 (99.0%) -IGKJ4*01 (100%), CDR-IMGT [12.3.10] (27-38.56-58.95-104)) (1-114) -20-mer tetrakis(tetraglycyl-seryl) li

Common Name

English

Immunoglobulin, anti-(human interleukin 3 receptor) (human-Mus musculus monoclonal APVO436 single-chain variable fragment VL-(GGGGS)4-VH) fusion protein with immunoglobulin G1 [5-serine,19-alanine,20-alanine,22-alanine,107-alanine,de-232-lysine] (human ?

Common Name

English

mipletamig [INN]

Common Name

English

immunoglobulin IG chain scFvkh-G1hCH2CH3-scFvhk dimer bisdisulfide, anti-[Homo sapiens IL3RA (interleukin 3 receptor subunit alpha, interleukin 3 receptor alpha (low affinity), CD123)] and anti-[Homo sapiens CD3E (CD3 epsilon, Leu-4)], Homo sapiens and h

Common Name

English

APVO436

Code

English

Classification Tree Code System Code

FDA ORPHAN DRUG

711019