Zeleciment rostudirsen

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 13:46:07 GMT 2025` Edited by `admin` on `Wed Apr 02 13:46:07 GMT 2025`
Protein Type	FAB
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	DL5BCM4SFN
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Fab-G1 VH-CH1 chain (1-227) [VH Musmus/Homsap (Mus musculus IGHV3-6*01 (84.5%) -(IGHD) -IGHJ2*01 (85.7%)L124>V (115)/Homo sapiens IGHV4-30-4*01 (82.8%) -(IGHD) -IGHJ4*01 (85.7%) L123>T (114), CDR-IMGT [9.7.12] (26-34.52-58.97-108)) (1-119) -Homo sapiens

Preferred Name

English

Zeleciment rostudirsen

Official Name

English

Immunoglobulin IgG1 Fab fragment, anti-(human and Macaca fascicularis transferrin receptors type 1) (human-Mus musculus monoclonal F5298 ?1-chain), disulfide with human-Mus musculus monoclonal F5298 ?-chain, N6-amide with RNA [P-deoxy-P-(dimethylamino)](

Common Name

English

Immunoglobulin Fab-G1kappa (VH-CH1_L-kappa), anti-[Homo sapiens TFRC (transferrin receptor, TfR1, TFR1, CD71)], monoclonal antibody, conjugated at lysine residues with rostudirsen groups

Common Name

English

zeleciment rostudirsen [INN]

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C203066

Created by admin on Wed Apr 02 13:46:07 GMT 2025 , Edited by admin on Wed Apr 02 13:46:07 GMT 2025

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CAS

2725863-42-1

Created by admin on Wed Apr 02 13:46:07 GMT 2025 , Edited by admin on Wed Apr 02 13:46:07 GMT 2025

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FDA UNII

DL5BCM4SFN

Created by admin on Wed Apr 02 13:46:07 GMT 2025 , Edited by admin on Wed Apr 02 13:46:07 GMT 2025

PRIMARY

INN

12543

Created by admin on Wed Apr 02 13:46:07 GMT 2025 , Edited by admin on Wed Apr 02 13:46:07 GMT 2025

PRIMARY

From	To
1_222	2_214
2_134	2_194
2_23	2_88
1_146	1_202
1_22	1_96

Related Record Type Details


					F6J6Y9R4HT

Zeleciment

PARENT -> CONJUGATE

Amount:

Related Record Type Details


					DL5BCM4SFN

Zeleciment rostudirsen

ACTIVE MOIETY

Comments:

Enables the production of a truncated dystrophin molecule

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1]			Amount:	PIDOLIC ACID	SZB83O1W42
AMINO_ACID_SUBSTITUTION			K	Amount:	Zeleciment rostudirsen oligonucleotid-lysine modification	3AR55D4G2D

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL