S-33138

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C22H23N3O2
Molecular Weight	361.4369
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12CN(CCC3=CC=C(NC(C)=O)C=C3)C[C@@]1([H])C4=CC(=CC=C4OC2)C#N

InChI

InChIKey=ZDZWIQDJFWTDAM-GHTZIAJQSA-N

InChI=1S/C22H23N3O2/c1-15(26)24-19-5-2-16(3-6-19)8-9-25-12-18-14-27-22-7-4-17(11-23)10-20(22)21(18)13-25/h2-7,10,18,21H,8-9,12-14H2,1H3,(H,24,26)/t18-,21+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C22H23N3O2
Molecular Weight	361.4369
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

PubMed

Title	Date	PubMed
The preferential dopamine D3 receptor antagonist S33138 inhibits cocaine reward and cocaine-triggered relapse to drug-seeking behavior in rats.	2009 Mar	19136017

Substance Class	Chemical Created by `admin` on `Sat Dec 16 11:36:45 GMT 2023` Edited by `admin` on `Sat Dec 16 11:36:45 GMT 2023`
Record UNII	DJ7ZL6XVM7
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

S-33138

Code

English

N-(4-(2-((3AS,9BR)-8-CYANO-3,3A,4,9B-TETRAHYDRO-1H-CHROMENO(3,4-C)PYRROL-2-YL)ETHYL)PHENYL)ACETAMIDE

Systematic Name

English

S33138

Code

English

ACETAMIDE, N-(4-(2-((3AS,9BR)-8-CYANO-1,3A,4,9B-TETRAHYDRO(1)BENZOPYRANO(3,4-C)PYRROL-2(3H)-YL)ETHYL)PHENYL)-

Systematic Name

English

Code System Code Type Description

MANUFACTURER PRODUCT INFORMATION

S-33138

Created by admin on Sat Dec 16 11:36:45 GMT 2023 , Edited by admin on Sat Dec 16 11:36:45 GMT 2023

PRIMARY

A preferential dopamine D3 versus D2 receptor antagonist and potential antipsychotic agent; it does not interact with histamine H1 and muscarinic receptors.

PUBCHEM

9841864

Created by admin on Sat Dec 16 11:36:45 GMT 2023 , Edited by admin on Sat Dec 16 11:36:45 GMT 2023

PRIMARY

CAS

245514-32-3

Created by admin on Sat Dec 16 11:36:45 GMT 2023 , Edited by admin on Sat Dec 16 11:36:45 GMT 2023

PRIMARY

FDA UNII

DJ7ZL6XVM7

Created by admin on Sat Dec 16 11:36:45 GMT 2023 , Edited by admin on Sat Dec 16 11:36:45 GMT 2023

PRIMARY

Related Record Type Details


					DJ7ZL6XVM7

S-33138

ACTIVE MOIETY

Comments:

In mice, S33138 (0.04-2.5 mg/kg i.p.) increased levels of mRNA encoding c-fos in D(3) receptor-rich Isles of Calleja and nucleus accumbens more potently than in D(2) receptor-rich striatum.