Syk Inhibitor II

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H15F3N6O
Molecular Weight	340.3037
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NCCNC1=NC(NC2=CC(=CC=C2)C(F)(F)F)=C(C=N1)C(N)=O

InChI

InChIKey=FQNFLNSVHWCZML-UHFFFAOYSA-N

InChI=1S/C14H15F3N6O/c15-14(16,17)8-2-1-3-9(6-8)22-12-10(11(19)24)7-21-13(23-12)20-5-4-18/h1-3,6-7H,4-5,18H2,(H2,19,24)(H2,20,21,22,23)

HIDE SMILES / InChI

Molecular Formula	C14H15F3N6O
Molecular Weight	340.3037
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Potency
Tyrosine-protein kinase SYK 21 Target ID: CHEMBL2599 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18938080	Inhibitor 8297	41.0 nM [IC50]
Tyrosine-protein kinase ZAP-70 1 Target ID: CHEMBL2803 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18077363	Inhibitor 8297	11200.0 nM [IC50]
Tyrosine-protein kinase BTK 24 Target ID: CHEMBL5251 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18077363	Inhibitor 8297	15500.0 nM [IC50]

Substance Class	Chemical Created by `admin` on `Sat Dec 16 12:18:52 UTC 2023` Edited by `admin` on `Sat Dec 16 12:18:52 UTC 2023`
Record UNII	DHY3UC4XFH
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Syk Inhibitor II

Common Name

English

K00592a

Code

English

2-(2-aminoethylamino)-4-[3-(trifluoromethyl)anilino]pyrimidine-5-carboxamide

Systematic Name

English

5-Pyrimidinecarboxamide, 2-[(2-aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-

Systematic Name

English

2-[(2-Aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-5-pyrimidinecarboxamide

Systematic Name

English

Code System Code Type Description

PUBCHEM

9549296

Created by admin on Sat Dec 16 12:18:52 UTC 2023 , Edited by admin on Sat Dec 16 12:18:52 UTC 2023

PRIMARY

CHEMBL

471901

Created by admin on Sat Dec 16 12:18:52 UTC 2023 , Edited by admin on Sat Dec 16 12:18:52 UTC 2023

PRIMARY

CAS

726695-51-8

Created by admin on Sat Dec 16 12:18:52 UTC 2023 , Edited by admin on Sat Dec 16 12:18:52 UTC 2023

PRIMARY

FDA UNII

DHY3UC4XFH

Created by admin on Sat Dec 16 12:18:52 UTC 2023 , Edited by admin on Sat Dec 16 12:18:52 UTC 2023

PRIMARY

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