For managing acute and chronic intoxications by arsenic and mercury compounds utnithiol is injected intramuscular or subcutaneous (5 – 10 ml of 5% solution). The treatment should be started as early as possible. In case of intoxications by arsenic compounds injections are every 6 – 8 hours the first day, 2 – 3 injections every 8 – 12 hours the second day, 1 – 2 injections the subsequent days. Children are made intramuscular injections in the doses 1 ml of 5% solution for each 10 kg of the body mass every 6 hours the first day; then 1 – 3 injections a day. In case of intoxications by mercury salts the preparation is injected for not less than 6 days. In case of intoxications by cardiac glicosides it is injected intramuscular or subcutaneous in the dose 5 or 10 ml of the unithiol 5% solution during the first 2 days. Injections are made 3 – 4 times a day. Then it is injected 1 – 2 times a day until the cardiotoxic action stops. In case of hepatocerebral degeneration 5 – 10 ml of the unithiol solution is prescribed for daily or in a day intramuscular injections, the course being 25 – 30 injections with an interval between the courses – 3 – 4 months. In case of diabetic polyneuropathy 5 ml of 5% solution is injected for 10 days. In case of chronic alcoholism the preparation is introduced intramuscular in dose 3 – 5 ml of 5% solution 2 – 3 times a week. For arresting the alcoholic delirium attacks 4 – 5ml of 5% solution is injected intramuscular. 1 ml of the preparation contains 50 mg of unithiol.

When HepG2 cells were co-treated with As3+ (25 uM) and DMPS (Unithiol) (0.02, 0.2, 1.0, or 2.0 mM), cellular arsenic was decreased with the increasing of DMPS concentration from 0.02 mM to 2.0 mM. DMPS at high concentration (>1.0 mM) dramatically decreased the accumulation of arsenic in HepG2 cells. The cellular arsenic was decreased from 5.72% to 0.13% when the cells were treated with 2.0 mM DMPS.