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Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Wed Apr 02 20:41:38 GMT 2025
Edited
by admin
on Wed Apr 02 20:41:38 GMT 2025
Protein Type MONOCLONAL ANTIBODY
Protein Sub Type IGG4|KAPPA
Sequence Origin HUMANIZED RABBIT
Sequence Type COMPLETE
Record UNII
DET5J756VL
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Umikibart
INN  
Official Name English
YYB-101
Preferred Name English
umikibart [INN]
Common Name English
YYB101
Code English
Immunoglobulin G4 [224-proline], anti-(human hepatocyte growth factor) (human-Oryctolagus cuniculus monoclonal YYB101 ?4-chain), disulfide with human-Oryctolagus cuniculus monoclonal YYB101 ?-chain, dimer
Common Name English
H-gamma4 heavy chain humanized (1-443) [VH (Homo sapiens IGHV3-23*04 (89.8%) -(IGHD) -IGHJ1*01 (100%), CDR-IMGT [8.8.9] (26-33.51-58.97-105)) (1-116)-Homo sapiens IGHG4*01, nG4m(a) CH2 L92, G4v5 h P10, G4v3 CH2 E1.2 (CH1 (117-214), hinge 1-12 S10>P (224)
Common Name English
immunoglobulin G4-kappa, anti-[Homo sapiens HGF (hepatocyte growth factor, scatter factor, SF, hepatopoeitin A)], humanized monoclonal antibody
Common Name English
Code System Code Type Description
CAS
2851478-58-3
Created by admin on Wed Apr 02 20:41:38 GMT 2025 , Edited by admin on Wed Apr 02 20:41:38 GMT 2025
PRIMARY
SMS_ID
300000054752
Created by admin on Wed Apr 02 20:41:38 GMT 2025 , Edited by admin on Wed Apr 02 20:41:38 GMT 2025
PRIMARY
NCI_THESAURUS
C176875
Created by admin on Wed Apr 02 20:41:38 GMT 2025 , Edited by admin on Wed Apr 02 20:41:38 GMT 2025
PRIMARY
INN
12925
Created by admin on Wed Apr 02 20:41:38 GMT 2025 , Edited by admin on Wed Apr 02 20:41:38 GMT 2025
PRIMARY
FDA UNII
DET5J756VL
Created by admin on Wed Apr 02 20:41:38 GMT 2025 , Edited by admin on Wed Apr 02 20:41:38 GMT 2025
PRIMARY
From To
1_22 1_96
2_22 2_96
2_130 4_215
2_143 2_199
2_257 2_317
1_130 3_215
2_363 2_421
3_23 3_88
3_135 3_195
4_23 4_88
4_135 4_195
1_143 1_199
1_222 2_222
1_225 2_225
1_257 1_317
1_363 1_421
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_293
N 2_293
Related Record Type Details
HUMAN HEPATOCYTE GROWTH FACTOR
TARGET->LIGAND
Related Record Type Details
Umikibart
ACTIVE MOIETY
antineoplastic

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO ACID REMOVAL [1_443] [2_443] C-TERMINUS K LYSINE K3Z4F929H6
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
Molecular Formula CHEMICAL
NIH
NCATS
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