U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
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Approval Year

Substance Class Protein
Created
by admin
on Tue Apr 01 20:57:08 GMT 2025
Edited
by admin
on Tue Apr 01 20:57:08 GMT 2025
Protein Type RECEPTOR
Protein Sub Type
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
DEI7IFD2OG
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DELTA-LIKE PROTEIN 4
Preferred Name English
.DELTA.-LIKE PROTEIN 4
Common Name English
DROSOPHILA DELTA HOMOLOG 4
Common Name English
DLL4
Common Name English
DELTA4
Common Name English
Code System Code Type Description
FDA UNII
DEI7IFD2OG
Created by admin on Tue Apr 01 20:57:08 GMT 2025 , Edited by admin on Tue Apr 01 20:57:08 GMT 2025
PRIMARY
UNIPROT
Q9NR61
Created by admin on Tue Apr 01 20:57:08 GMT 2025 , Edited by admin on Tue Apr 01 20:57:08 GMT 2025
PRIMARY
From To
1_24 1_28
1_35 1_48
1_227 1_238
1_233 1_244
1_262 1_274
1_268 1_284
1_286 1_295
1_302 1_313
1_307 1_322
1_324 1_333
1_340 1_351
1_345 1_362
1_364 1_373
1_380 1_391
1_385 1_400
1_402 1_411
1_418 1_429
1_423 1_438
1_440 1_449
1_458 1_469
1_463 1_480
1_482 1_491
Glycosylation Link Type Site
N 1_82
N 1_157
N 1_179
N 1_367
Related Record Type Details
INHIBITOR -> TARGET
Specifically binds to DLL4 and prevents its interaction with Notch receptors, thereby inhibiting Notch-mediated signaling and gene transcription, which may block tumor angiogenesis and eventually the inhibition of tumor cell growth.
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL