Pegpleranib Sodium

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Investigational

Investigational

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Mon Mar 31 22:10:36 GMT 2025` Edited by `admin` on `Mon Mar 31 22:10:36 GMT 2025`
Nucleic Acid Type	APTAMER
Sequence Type	COMPLETE
Record UNII	DD50D2QKH1
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FOVISTA

Preferred Name

English

Pegpleranib Sodium

Official Name

English

E-10030

Code

English

Pegpleranib sodium [WHO-DD]

Common Name

English

E-01AJ

Code

English

E01AJ

Code

English

X01E

Code

English

X-01E

Code

English

P5'.1-ester of 2'-deoxy-5'-O-phosphonocytidylyl-(3'?5')-2'-deoxyadenylyl-(3'?5')-2'-deoxyguanylyl-(3'?5')-2'-deoxyguanylyl-(3'?5')-2'-deoxycytidylyl-(3'?5')-2'-deoxy-2'-fluorouridylyl-(3'?5')-2'-deoxyadenylyl-(3'?5')-2'-deoxy-2'-fluorocytidylyl-(3'?5')-2

Common Name

English

PEGPLERANIB SODIUM [USAN]

Common Name

English

E10030

Code

English

Poly(oxy-1,2-ethanediyl), ?-hydro-?-methoxy-, 5?-ester with DNA d(C-A-G-G-C-(2?-deoxy-2?-fluoro)rU-A-(2?-deoxy-2?-fluoro)rC-rGm(oxyphosphinicooxy-1,2-ethanediyloxy-1,2-ethanediyloxy-1,2-ethanediyloxy-1,2-ethanediyloxy-1,2-ethanediyloxy-1,2-ethanediyloxyp

Common Name

English

Code System Code Type Description

ChEMBL

CHEMBL3301576

Created by admin on Mon Mar 31 22:10:36 GMT 2025 , Edited by admin on Mon Mar 31 22:10:36 GMT 2025

PRIMARY

USAN

BC-44

Created by admin on Mon Mar 31 22:10:36 GMT 2025 , Edited by admin on Mon Mar 31 22:10:36 GMT 2025

PRIMARY

NCI_THESAURUS

C170304

Created by admin on Mon Mar 31 22:10:36 GMT 2025 , Edited by admin on Mon Mar 31 22:10:36 GMT 2025

PRIMARY

FDA UNII

DD50D2QKH1

Created by admin on Mon Mar 31 22:10:36 GMT 2025 , Edited by admin on Mon Mar 31 22:10:36 GMT 2025

PRIMARY

SMS_ID

300000044558

Created by admin on Mon Mar 31 22:10:36 GMT 2025 , Edited by admin on Mon Mar 31 22:10:36 GMT 2025

PRIMARY

DRUG BANK

DBSALT002614

Created by admin on Mon Mar 31 22:10:36 GMT 2025 , Edited by admin on Mon Mar 31 22:10:36 GMT 2025

PRIMARY

CAS

1449390-73-1

Created by admin on Mon Mar 31 22:10:36 GMT 2025 , Edited by admin on Mon Mar 31 22:10:36 GMT 2025

PRIMARY

Sugar	Site Range	Site Count
Deoxyribose (DNA)	1_1-1_5;1_7;1_10-1_13;1_15;1_17-1_18;1_22-1_25;1_30	18 / 30
2'-O-Methyl-Ribose	1_9;1_14;1_16;1_21;1_29	5 / 30
2'-Fluoro-Ribose	1_6;1_8;1_19-1_20;1_26-1_28	7 / 30

Linkage	Site Range	Site Count
	1_10;1_22	2 / 29
	1_2-1_9;1_11-1_21;1_23-1_30	27 / 29

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOSIDE_SUBSTITUTION	[1_30]	SITE_SPECIFIC			UNSPECIFIED SUBSTANCE	f592b06d (not in database)
NUCLEOTIDE SUBSTITUTION	[1_9]	SITE_SPECIFIC			(5'-PEG6-3' SODIUM)-2'-O-METHYLGUANOSINE	CHW8AH5D06
NUCLEOTIDE SUBSTITUTION	[1_1]	5'-TERMINUS			PEGPLERANIB SODIUM 5'- MODIFICATION	C40W0PY403
NUCLEOTIDE SUBSTITUTION	[1_21]	SITE_SPECIFIC			(5'-PEG6-3' SODIUM)-2'-O-METHYLADENOSINE	WPH42PU1B3

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(sizeexclusionchromatography)	CHEMICAL