Cesnicabtagene Autoleucel

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Wed Apr 02 20:21:28 GMT 2025` Edited by `admin` on `Wed Apr 02 20:21:28 GMT 2025`
Source Materials Class	ORGANISM
Source Materials Type	AUTOLOGOUS HUMAN
Source Materials State	LIVE GENETICALLY MODIFIED
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	blood cell
Fraction Material Type	cell
Fraction Name	cd4+ and cd8+ enriched t cells
Record UNII	DCY3M5W6TC
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

autologous T lymphocytes obtained from peripheral blood mononuclear cells (PBMC) by leukapheresis, transduced with a self-inactivating, non-replicating lentiviral vector encoding a chimeric antigen receptor (CAR) targeting the B-cell maturation antigen (

Preferred Name

English

Cesnicabtagene Autoleucel

Official Name

English

cesnicabtagene autoleucel [INN]

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C176769

Created by admin on Wed Apr 02 20:21:28 GMT 2025 , Edited by admin on Wed Apr 02 20:21:28 GMT 2025

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INN

13034

Created by admin on Wed Apr 02 20:21:28 GMT 2025 , Edited by admin on Wed Apr 02 20:21:28 GMT 2025

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FDA UNII

DCY3M5W6TC

Created by admin on Wed Apr 02 20:21:28 GMT 2025 , Edited by admin on Wed Apr 02 20:21:28 GMT 2025

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SMS_ID

300000044021

Created by admin on Wed Apr 02 20:21:28 GMT 2025 , Edited by admin on Wed Apr 02 20:21:28 GMT 2025

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Related Record Type Details


					PK6VHJAIBD

TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 17

TARGET->CYTOTOXIC T-CELL

Amount:

Related Record Type Details


					DCY3M5W6TC

Cesnicabtagene Autoleucel

ACTIVE MOIETY

Amount:

Agent Modifications

Modification Process	Modification Role	Modification Type	Fragment Name	Fragment ID
CULTURE			INTERLEUKIN-5	9O1TT75I7L
CULTURE			INTERLEUKIN-7 HUMAN RECOMBINANT	418XB47Y71
CULTURE	ACTIVATOR	BIOLOGICAL	ANTI-CD3/ANTI-CD28 4.5 MICRON MAGNETIC BEADS	PA28ZKP50M
LENTIVIRAL TRANSFECTION	TRANSFECTION	GENE MODIFICATION	Cesnicabtagene autoleucel lentiviral vector	PKW5458C47

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
VECTOR EXPRESSED PROTEIN					Cesnicabtagene autoleucel expressed anti-BCMA chimeric antigen receptor (CAR)	H2YZ7NB24R
INSERTED GENE EXPRESSION VECTOR					Cesnicabtagene autoleucel transgene insert encoding anti-BCMA chimeric antigen receptor (CAR)	5R4T3733Y7