Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C12H10N2O |
| Molecular Weight | 198.2206 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[O-]\[N+](=N\C1=CC=CC=C1)C2=CC=CC=C2
InChI
InChIKey=GAUZCKBSTZFWCT-BUHFOSPRSA-N
InChI=1S/C12H10N2O/c15-14(12-9-5-2-6-10-12)13-11-7-3-1-4-8-11/h1-10H/b14-13+
| Molecular Formula | C12H10N2O |
| Molecular Weight | 198.2206 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Optical Activity | NONE |
Z- Azoxybenzene has attracted limited investigational interest. An early stage investigation was conducted on rats to determine the effect of Z-azoxybenzene on liver enzymes. It was found that oral administration of azoxybenzene caused a time and dose-dependent decrease for cytochrome P-450 as well as in the ability of aminopyrine-N-demethylation and aniline hydroxylation. In both male and female rats, there was retardation in body weight gain and increases in relative liver weight, and an increase in the amount of microsomal cytochrome b5.
Approval Year
Sample Use Guides
In Vivo Use Guide
Curator's Comment: Oral administrations of azoxybenzene (0, 25, 50 and 100 mg/kg b.w.) over a period up to 7 days caused a time and dose dependent decrease in the amount of cytochrome P-450 as well as in the ability of aminopyrine-N-demethylation and aniline hydroxylation in the hepatic microsomes of male and female rats.
in rats: 25, 50 and 100 mg/kg b.w. over a period up to 7 days
Route of Administration:
Oral
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 23:05:12 GMT 2025
by
admin
on
Mon Mar 31 23:05:12 GMT 2025
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| Record UNII |
DC1P3JE72O
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| Record Status |
Validated (UNII)
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| Record Version |
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DC1P3JE72O
Created by
admin on Mon Mar 31 23:05:12 GMT 2025 , Edited by admin on Mon Mar 31 23:05:12 GMT 2025
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21650-65-7
Created by
admin on Mon Mar 31 23:05:12 GMT 2025 , Edited by admin on Mon Mar 31 23:05:12 GMT 2025
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m2186
Created by
admin on Mon Mar 31 23:05:12 GMT 2025 , Edited by admin on Mon Mar 31 23:05:12 GMT 2025
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PRIMARY | Merck Index |