Pegevongitide

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 09:32:12 GMT 2025` Edited by `admin` on `Wed Apr 02 09:32:12 GMT 2025`
Protein Type	PEPTIDE
Protein Sub Type
Sequence Origin	SYNTHETIC
Sequence Type	COMPLETE
Record UNII	DB2XB649O5
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

N<sup>2.1<sup> -{3-[(2-{[?-(3-[?-(2-{[3-(L -histidyl-L-histidyl-L-histidyl-L-arginyl-L-histidyl-L-seryl-L-phenylalanin-N<sup>2.1<sup> -yl)-3-oxopropyl]sulfanyl}acetamido)poly(oxyethylene)-?-yl]-2,2-bis{[?-(2-{[3-(L-histidyl-L-histidyl-L-histidyl-L-arginy

Preferred Name

English

Pegevongitide

Official Name

English

pegevongitide [INN]

Common Name

English

Poly(oxy-1,2-ethanediyl), ?-hydro-?-hydroxy- (10K), ether with 2,2-bis(hydroxymethyl)-1,3-propanediol (4:1), 1,1?,1??,1???-tetraether with N-[3-[[2-[(2-hydroxyethyl)amino]-2-oxoethyl]thio]-1-oxopropyl]-L-histidyl-L-histidyl-L-histidyl-L-arginyl-L-histidy

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C211765

Created by admin on Wed Apr 02 09:32:12 GMT 2025 , Edited by admin on Wed Apr 02 09:32:12 GMT 2025

PRIMARY

CAS

2988012-71-9

Created by admin on Wed Apr 02 09:32:12 GMT 2025 , Edited by admin on Wed Apr 02 09:32:12 GMT 2025

PRIMARY

FDA UNII

DB2XB649O5

Created by admin on Wed Apr 02 09:32:12 GMT 2025 , Edited by admin on Wed Apr 02 09:32:12 GMT 2025

PRIMARY

INN

13396

Created by admin on Wed Apr 02 09:32:12 GMT 2025 , Edited by admin on Wed Apr 02 09:32:12 GMT 2025

PRIMARY

Linkage Type	Residue Index
CROSSLINK	1_1	2_1	3_1	4_1

Related Record Type Details


					DB2XB649O5

Pegevongitide

ACTIVE MOIETY

Comments:

In COVID-19 patients, Tie2 activation is compromised owing to the high level of circulating Angioppoietin-2 (Angp-2), an antagonist of Angpt-1, leading to lung vasculature inflammation along with EC apoptosis and permeability, triggering ARDS

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1] [3_1] [4_1]	SITE_SPECIFIC			Pegevongitide histidine modification	IDL31SQ6LT

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL