Rugecitide

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 06:34:58 GMT 2025` Edited by `admin` on `Wed Apr 02 06:34:58 GMT 2025`
Protein Type	PEPTIDE
Protein Sub Type
Sequence Origin	SYNTHETIC
Sequence Type	COMPLETE
Record UNII	DAS1FKX1LY
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LY-3461767

Preferred Name

English

Rugecitide

Official Name

English

RUGECITIDE [USAN]

Common Name

English

LY3461767

Code

English

Synthetic peptide (GGGGSG) fusion protein with 5-50-human neuregulin 4 [25-glutamine,47-lysine]

Common Name

English

rugecitide [INN]

Common Name

English

Code System Code Type Description

FDA UNII

DAS1FKX1LY

Created by admin on Wed Apr 02 06:34:58 GMT 2025 , Edited by admin on Wed Apr 02 06:34:58 GMT 2025

PRIMARY

CAS

2938226-27-6

Created by admin on Wed Apr 02 06:34:58 GMT 2025 , Edited by admin on Wed Apr 02 06:34:58 GMT 2025

PRIMARY

USAN

MN-76

Created by admin on Wed Apr 02 06:34:58 GMT 2025 , Edited by admin on Wed Apr 02 06:34:58 GMT 2025

PRIMARY

NCI_THESAURUS

C211764

Created by admin on Wed Apr 02 06:34:58 GMT 2025 , Edited by admin on Wed Apr 02 06:34:58 GMT 2025

PRIMARY

SMS_ID

300000056942

Created by admin on Wed Apr 02 06:34:58 GMT 2025 , Edited by admin on Wed Apr 02 06:34:58 GMT 2025

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INN

13522

Created by admin on Wed Apr 02 06:34:58 GMT 2025 , Edited by admin on Wed Apr 02 06:34:58 GMT 2025

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From	To
1_11	1_25
1_19	1_36
1_38	1_47

Related Record Type Details


					DAS1FKX1LY

ACTIVE MOIETY

Comments:

The ability of LY3461767 to agonize HER4/ HER2 signaling, while avoiding agonism of HER3/ HER2 signaling, was demonstrated in appropriate in vitro cell-based assays. The desired beneficial pharmacology of improved left ventricular ejection fraction (LVEF) was demonstrated in a rat model

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL