Lonvoguran

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Wed Apr 02 20:32:19 GMT 2025` Edited by `admin` on `Wed Apr 02 20:32:19 GMT 2025`
Nucleic Acid Type	OLIGONUCLEOTIDE
Sequence Origin	SYNTHETIC
Sequence Type	COMPLETE
Record UNII	D8UQ4B2T7M
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

RNA (synthetic sgRNA human gene KLKB1-targeting guide RNA CR005962 and tracrRNA-specifying)

Preferred Name

English

Lonvoguran

Official Name

English

all-P-ambo-2'-O-methyl-P-thioguanylyl-(3'?5')-2'-O-methyl-P-thioguanylyl-(3'?5')-2'-O-methyl-P-thioadenylyl-(3'?5')-uridylyl-(3'?5')-uridylyl-(3'?5')-guanylyl-(3'?5')-cytidylyl-(3'?5')-guanylyl-(3'?5')-uridylyl-(3'?5')-adenylyl-(3'?5')-uridylyl-(3'?5')-g

Common Name

English

lonvoguran [INN]

Common Name

English

Code System Code Type Description

FDA UNII

D8UQ4B2T7M

Created by admin on Wed Apr 02 20:32:19 GMT 2025 , Edited by admin on Wed Apr 02 20:32:19 GMT 2025

PRIMARY

NCI_THESAURUS

C206936

Created by admin on Wed Apr 02 20:32:19 GMT 2025 , Edited by admin on Wed Apr 02 20:32:19 GMT 2025

PRIMARY

INN

13064

Created by admin on Wed Apr 02 20:32:19 GMT 2025 , Edited by admin on Wed Apr 02 20:32:19 GMT 2025

PRIMARY

SMS_ID

300000036198

Created by admin on Wed Apr 02 20:32:19 GMT 2025 , Edited by admin on Wed Apr 02 20:32:19 GMT 2025

PRIMARY

CAS

2844372-34-3

Created by admin on Wed Apr 02 20:32:19 GMT 2025 , Edited by admin on Wed Apr 02 20:32:19 GMT 2025

PRIMARY

Sugar	Site Range	Site Count
D-Ribose (RNA)	1_4-1_28;1_41-1_68;1_78-1_100	76 / 100
2'-O-Methyl-Ribose	1_1-1_3;1_29-1_40;1_69-1_77	24 / 100

Linkage	Site Range	Site Count
Phosphate	1_5-1_96	92 / 99
Phosporothioate	1_2-1_4;1_97-1_100	7 / 99

Related Record Type Details


					D8UQ4B2T7M

ACTIVE MOIETY

Comments:

gene editing agent (kallikrein B1)

Amount: