Durcabtagene Autoleucel

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Sat Dec 16 19:48:17 UTC 2023` Edited by `admin` on `Sat Dec 16 19:48:17 UTC 2023`
Source Materials Class	ORGANISM
Source Materials Type	AUTOLOGOUS HUMAN
Source Materials State	LIVE GENETICALLY MODIFIED
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	BLOOD
Fraction Name	Enriched for CD4+ and CD8+ TCells
Record UNII	D6ZL787LZ9
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Durcabtagene Autoleucel

Official Name

English

durcabtagene autoleucel [INN]

Common Name

English

autologous T lymphocytes obtained from peripheral blood mononuclear cells by leukapheresis, transduced with a self-inactivating, non-replicating lentiviral vector encoding a chimeric antigen receptor (CAR) targeting human B cell maturation antigen (BCMA)

Common Name

English

Code System Code Type Description

FDA UNII

D6ZL787LZ9

Created by admin on Sat Dec 16 19:48:18 UTC 2023 , Edited by admin on Sat Dec 16 19:48:18 UTC 2023

PRIMARY

NCI_THESAURUS

C199006

Created by admin on Sat Dec 16 19:48:18 UTC 2023 , Edited by admin on Sat Dec 16 19:48:18 UTC 2023

PRIMARY

INN

12461

Created by admin on Sat Dec 16 19:48:18 UTC 2023 , Edited by admin on Sat Dec 16 19:48:18 UTC 2023

PRIMARY

Related Record Type Details


					P050J5FWC5

INTERFERON GAMMA

CONSTITUENT MAY BE PRESENT -> PARENT

Comments:

T lymphocytes secrete interferon gamma (IFN-γ) and IL-2 following co-culture with BCMA-expressing cells

Amount:


					PK6VHJAIBD

TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 17

TARGET->CYTOTOXIC T-CELL

Amount:

Related Record Type Details


					D6ZL787LZ9

Durcabtagene Autoleucel

ACTIVE MOIETY

Amount:

Agent Modifications

Modification Process	Modification Role	Modification Type	Fragment Name	Fragment ID
CULTURE		BIOLOGICAL	HUMAN INTERLEUKIN-2	FNO32LO217
CULTURE	ACTIVATOR	BIOLOGICAL	UNSPECIFIED SUBSTANCE	4e4ac683
LENTIVIRAL TRANSFECTION	TRANSFECTION	BIOLOGICAL	Durcabtagene autoleucel lentiviral vector	JZW3XX47M8

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
VECTOR EXPRESSED PROTEIN					Durcabtagene autoleucel expressed chimeric antigen receptor (CAR)	R79PHX2R8B
INSERTED GENE EXPRESSION VECTOR					Durcabtagene autoleucel transgene insert	L85KQ4892V