U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Structurally Diverse
Created
by admin
on Sat Dec 16 19:48:17 GMT 2023
Edited
by admin
on Sat Dec 16 19:48:17 GMT 2023
Source Materials Class ORGANISM
Source Materials Type AUTOLOGOUS HUMAN
Source Materials State LIVE GENETICALLY MODIFIED
Source Materials Parent
Part BLOOD
Fraction Name Enriched for CD4+ and CD8+ TCells
Record UNII
D6ZL787LZ9
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Durcabtagene Autoleucel
INN  
Official Name English
durcabtagene autoleucel [INN]
Common Name English
autologous T lymphocytes obtained from peripheral blood mononuclear cells by leukapheresis, transduced with a self-inactivating, non-replicating lentiviral vector encoding a chimeric antigen receptor (CAR) targeting human B cell maturation antigen (BCMA)
Common Name English
Code System Code Type Description
FDA UNII
D6ZL787LZ9
Created by admin on Sat Dec 16 19:48:18 GMT 2023 , Edited by admin on Sat Dec 16 19:48:18 GMT 2023
PRIMARY
NCI_THESAURUS
C199006
Created by admin on Sat Dec 16 19:48:18 GMT 2023 , Edited by admin on Sat Dec 16 19:48:18 GMT 2023
PRIMARY
INN
12461
Created by admin on Sat Dec 16 19:48:18 GMT 2023 , Edited by admin on Sat Dec 16 19:48:18 GMT 2023
PRIMARY
Related Record Type Details
CONSTITUENT MAY BE PRESENT -> PARENT
T lymphocytes secrete interferon gamma (IFN-γ) and IL-2 following co-culture with BCMA-expressing cells
TARGET->CYTOTOXIC T-CELL
Related Record Type Details
ACTIVE MOIETY

Agent Modifications

Modification Process Modification Role Modification Type Amount Fragment Name Fragment ID
CULTURE BIOLOGICAL HUMAN INTERLEUKIN-2 FNO32LO217
CULTURE ACTIVATOR BIOLOGICAL UNSPECIFIED SUBSTANCE 4e4ac683
LENTIVIRAL TRANSFECTION TRANSFECTION BIOLOGICAL Durcabtagene autoleucel lentiviral vector JZW3XX47M8

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
VECTOR EXPRESSED PROTEIN Durcabtagene autoleucel expressed chimeric antigen receptor (CAR) R79PHX2R8B
INSERTED GENE EXPRESSION VECTOR Durcabtagene autoleucel transgene insert L85KQ4892V