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Details

Stereochemistry ABSOLUTE
Molecular Formula C17H21NO2
Molecular Weight 271.3541
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of NISOXETINE, (-)-

SMILES

CNCC[C@H](OC1=CC=CC=C1OC)C2=CC=CC=C2

InChI

InChIKey=ITJNARMNRKSWTA-HNNXBMFYSA-N
InChI=1S/C17H21NO2/c1-18-13-12-15(14-8-4-3-5-9-14)20-17-11-7-6-10-16(17)19-2/h3-11,15,18H,12-13H2,1-2H3/t15-/m0/s1

HIDE SMILES / InChI
Molecular Formula C17H21NO2
Molecular Weight 271.3541
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

There is not much information related to the S isomer of nisoxetine. It is known, that (S)-nisoxetine is 20 times less active than R-enantiomer. And that racemic nisoxetine currently doesn’t have any clinical application in spite of had been researched as an antidepressant.

Approval Year

Unknown
149124
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
PubMed

PubMed

TitleDatePubMed
Comparison of (R)-[3H]tomoxetine and (R/S)-[3H]nisoxetine binding in rat brain.
1995-06
Patents

Patents

20070010678
4

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Mon Mar 31 20:39:18 GMT 2025
Edited
by admin
on Mon Mar 31 20:39:18 GMT 2025
Record UNII
D6W2AVH65E
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
NISOXETINE, (S)-
Preferred Name English
NISOXETINE, (-)-
Common Name English
BENZENEPROPANAMINE, .GAMMA.-(2-METHOXYPHENOXY)-N-METHYL-, (.GAMMA.S)-
Systematic Name English
BENZENEPROPANAMINE, .GAMMA.-(2-METHOXYPHENOXY)-N-METHYL-, (S)-
Systematic Name English
(S)-N-METHYL-3-(2-METHOXYPHENOXY)-3-PHENYLPROPYLAMINE
Systematic Name English
Code System Code Type Description
PUBCHEM
6603938
Created by admin on Mon Mar 31 20:39:18 GMT 2025 , Edited by admin on Mon Mar 31 20:39:18 GMT 2025
PRIMARY
CAS
112066-66-7
Created by admin on Mon Mar 31 20:39:18 GMT 2025 , Edited by admin on Mon Mar 31 20:39:18 GMT 2025
PRIMARY
FDA UNII
D6W2AVH65E
Created by admin on Mon Mar 31 20:39:18 GMT 2025 , Edited by admin on Mon Mar 31 20:39:18 GMT 2025
PRIMARY
NIH
NCATS
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