Rinvatercept

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 19:21:02 GMT 2025` Edited by `admin` on `Wed Apr 02 19:21:02 GMT 2025`
Protein Type	FC FUSION PROTEIN
Protein Sub Type	IGG1
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	D674N274QK
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Activin receptor type 2 (synthetic human extracellular domain 109-amino acid fragment) fusion protein with peptide linker (GGG) fusion protein with immunoglobulin G1 (human ?1-chain Fc region), dimer

Preferred Name

English

Rinvatercept

Official Name

English

glycyl (1)-chimeric N-terminal (1-108)-peptide (2-109) combined from the sequences of the extracellular domains of the human activin type 2A and 2B receptors (ACTR-2A/B, ACVR2A/B, activin receptor type IIA/B, ACTR-IIA/B, EC:2.7.11.30), fused via a G3 pep

Common Name

English

rinvatercept [INN]

Common Name

English

Code System Code Type Description

INN

13442

Created by admin on Wed Apr 02 19:21:02 GMT 2025 , Edited by admin on Wed Apr 02 19:21:02 GMT 2025

PRIMARY

CAS

2996105-98-5

Created by admin on Wed Apr 02 19:21:02 GMT 2025 , Edited by admin on Wed Apr 02 19:21:02 GMT 2025

PRIMARY

FDA UNII

D674N274QK

Created by admin on Wed Apr 02 19:21:02 GMT 2025 , Edited by admin on Wed Apr 02 19:21:02 GMT 2025

PRIMARY

From	To
1_121	2_121
1_118	2_118
1_259	1_317
2_259	2_317
1_153	1_213
2_153	2_213
1_87	1_92
2_87	2_92
1_73	1_85
2_73	2_85
1_67	1_86
2_67	2_86
1_32	1_60
2_32	2_60
1_12	1_42
2_12	2_42

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_25
N	1_48
N	1_189
N	2_25
N	2_48
N	2_189
O	1_115
O	1_131
O	2_115
O	2_131

Related Record Type Details


					D674N274QK

Rinvatercept

ACTIVE MOIETY

Comments:

neuromuscular diseases

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_339] [2_339]	C-TERMINUS	K		LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
ACTR-2B	PROTEIN FEATURE
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
ACTR-2A	PROTEIN FEATURE