Details
| Stereochemistry | UNKNOWN |
| Molecular Formula | C18H26N2S |
| Molecular Weight | 302.477 |
| Optical Activity | ( + ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCN1C2=C(C=CC=C2)C3=C1C(C)(CCN(C)C)SCC3
InChI
InChIKey=BRPOADLGOFPKKJ-UHFFFAOYSA-N
InChI=1S/C18H26N2S/c1-5-20-16-9-7-6-8-14(16)15-10-13-21-18(2,17(15)20)11-12-19(3)4/h6-9H,5,10-13H2,1-4H3
| Molecular Formula | C18H26N2S |
| Molecular Weight | 302.477 |
| Charge | 0 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
Tandamine was developed as a selective serotonin reuptake inhibitor for the treatment of depression. Tandamine participated in clinical trials in hospitalized depressed patients, where it showed that the well-tolerated drug could be of some benefit for retarded depressions. In addition, was found in human volunteers, that tandamine possessed significant anticholinergic activity, to reduce appetite and to produce sedation. However, this drug has never been marketed.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Effects of tandamine and pirandamine, new potential antidepressants, on the brain uptake of norepinephrine and 5-hydroxytryptamine and related activities. | 1976 May 5 |
|
| Clinical pharmacological studies of tandamine, a potential antidepressive drug. | 1977 Mar 23 |
|
| Effect of acute and chronic treatment of tandamine, a new heterocyclic antidepressant, on biogenic amine metabolism and related activities. | 1979 Sep |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 04:17:47 GMT 2023
by
admin
on
Sat Dec 16 04:17:47 GMT 2023
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| Record UNII |
D38V2K62U7
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| Record Status |
Validated (UNII)
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| Record Version |
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-
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62481-67-8
Created by
admin on Sat Dec 16 04:17:47 GMT 2023 , Edited by admin on Sat Dec 16 04:17:47 GMT 2023
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D38V2K62U7
Created by
admin on Sat Dec 16 04:17:47 GMT 2023 , Edited by admin on Sat Dec 16 04:17:47 GMT 2023
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39187
Created by
admin on Sat Dec 16 04:17:47 GMT 2023 , Edited by admin on Sat Dec 16 04:17:47 GMT 2023
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PRIMARY |
| Related Record | Type | Details | ||
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ENANTIOMER -> ENANTIOMER |
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