DEPEMOKIMAB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 07:03:25 GMT 2025` Edited by `admin` on `Wed Apr 02 07:03:25 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1\|KAPPA
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	D16EQP0KKH
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

depemokimab [INN]

Preferred Name

English

DEPEMOKIMAB

Official Name

English

DEPEMOKIMAB [USAN]

Common Name

English

Depemokimab [WHO-DD]

Common Name

English

GSK3511294

Code

English

GSK-3511294

Code

English

IMMUNOGLOBULIN G1-KAPPA, ANTI-(HOMO SAPIENS IL5 (INTERLEUKIN 5, IL-5)), HUMANIZED MONOCLONAL ANTIBODY; GAMMA1 HEAVY CHAIN HUMANIZED (1-449) (VH HUMANIZED (HOMO SAPIENS IGHV2-70*19 (75.8%)-(IGHD)-IGHJ4*01 (85.7%)) CDR-IMGT (8.7.13) (26-33.51-57.96-108) (1

Common Name

English

RECOMBINANT HUMAN IgG1 KAPPA ANTI-IL-5 MONOCLONAL ANTIBODY GSK3511294

Common Name

English

AQ82742999

Code

English

IMMUNOGLOBULIN G1, ANTI-(HUMAN INTERLEUKIN 5) (HUMAN-MUS MUSCULUS MONOCLONAL GSK3511294 .GAMMA.1-CHAIN), DISULFIDE WITH HUMAN-MUS MUSCULUS MONOCLONAL GSK3511294 .KAPPA.-CHAIN, DIMER

Common Name

English

AQ-82742999

Code

English

Code System Code Type Description

CAS

2243274-14-6

Created by admin on Wed Apr 02 07:03:25 GMT 2025 , Edited by admin on Wed Apr 02 07:03:25 GMT 2025

PRIMARY

USAN

JK-143

Created by admin on Wed Apr 02 07:03:25 GMT 2025 , Edited by admin on Wed Apr 02 07:03:25 GMT 2025

PRIMARY

INN

11449

Created by admin on Wed Apr 02 07:03:25 GMT 2025 , Edited by admin on Wed Apr 02 07:03:25 GMT 2025

PRIMARY

NCI_THESAURUS

C175768

Created by admin on Wed Apr 02 07:03:25 GMT 2025 , Edited by admin on Wed Apr 02 07:03:25 GMT 2025

PRIMARY

FDA UNII

D16EQP0KKH

Created by admin on Wed Apr 02 07:03:25 GMT 2025 , Edited by admin on Wed Apr 02 07:03:25 GMT 2025

PRIMARY

SMS_ID

300000028753

Created by admin on Wed Apr 02 07:03:25 GMT 2025 , Edited by admin on Wed Apr 02 07:03:25 GMT 2025

PRIMARY

From	To
4_140	4_200
4_23	4_94
3_140	3_200
3_23	3_94
2_369	2_427
2_263	2_323
2_222	4_220
2_146	2_202
2_22	2_95
1_369	1_427
1_263	1_323
1_231	2_231
1_228	2_228
1_222	3_220
1_146	1_202
1_22	1_95

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_299
N	2_299

Related Record Type Details


					9O1TT75I7L

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					D16EQP0KKH

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_449] [2_449]	C-TERMINUS			LYSINE	K3Z4F929H6
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL