Approval Year
| Substance Class |
Protein
Created
by
admin
on
Edited
Sat Dec 16 14:00:29 GMT 2023
by
admin
on
Sat Dec 16 14:00:29 GMT 2023
|
| Protein Type | STRUCTURAL PROTEIN |
| Protein Sub Type | |
| Sequence Origin | HUMAN |
| Sequence Type | COMPLETE |
| Record UNII |
D0J3FHB0NT
|
| Record Status |
Validated (UNII)
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| Record Version |
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-
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| Code System | Code | Type | Description | ||
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P21333
Created by
admin on Sat Dec 16 14:00:29 GMT 2023 , Edited by admin on Sat Dec 16 14:00:29 GMT 2023
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PRIMARY | |||
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D0J3FHB0NT
Created by
admin on Sat Dec 16 14:00:29 GMT 2023 , Edited by admin on Sat Dec 16 14:00:29 GMT 2023
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
INHIBITOR -> TARGET |
PTI-125 is a filamin A (FLNA) binding compound. By restoring FLNA’s native conformation, the sponsor hypothesizes that PTI-125 prevents or reverses the FLNA – α7-nicotinic acetylcholine receptor (α7nAChR) association and beta amyloid1-42 (Aβ42) toxic signaling via α7nAChR, thereby preventing the development of neurofibrillary tangles and subsequent neurodegeneration.
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| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
|---|---|---|---|---|---|---|
| MOL_WEIGHT:NUMBER(CALCULATED) | CHEMICAL |
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