Approval Year
| Substance Class |
Protein
Created
by
admin
on
Edited
Tue Apr 01 21:59:01 GMT 2025
by
admin
on
Tue Apr 01 21:59:01 GMT 2025
|
| Protein Type | STRUCTURAL PROTEIN |
| Protein Sub Type | |
| Sequence Origin | HUMAN |
| Sequence Type | COMPLETE |
| Record UNII |
D0J3FHB0NT
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| Record Status |
Validated (UNII)
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| Record Version |
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-
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| Code System | Code | Type | Description | ||
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P21333
Created by
admin on Tue Apr 01 21:59:01 GMT 2025 , Edited by admin on Tue Apr 01 21:59:01 GMT 2025
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PRIMARY | |||
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D0J3FHB0NT
Created by
admin on Tue Apr 01 21:59:01 GMT 2025 , Edited by admin on Tue Apr 01 21:59:01 GMT 2025
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
INHIBITOR -> TARGET |
PTI-125 is a filamin A (FLNA) binding compound. By restoring FLNA’s native conformation, the sponsor hypothesizes that PTI-125 prevents or reverses the FLNA – ?7-nicotinic acetylcholine receptor (?7nAChR) association and beta amyloid1-42 (A?42) toxic signaling via ?7nAChR, thereby preventing the development of neurofibrillary tangles and subsequent neurodegeneration.
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| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
|---|---|---|---|---|---|---|
| MOL_WEIGHT:NUMBER(CALCULATED) | CHEMICAL |
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