3,6-DIMETHYLMANGOSTIN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C26H30O6
Molecular Weight	438.5128
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC2=C(C(=O)C3=C(O)C(CC=C(C)C)=C(OC)C=C3O2)C(CC=C(C)C)=C1OC

InChI

InChIKey=FCIKYGUVHWZSJV-UHFFFAOYSA-N

InChI=1S/C26H30O6/c1-14(2)8-10-16-18(29-5)12-20-23(24(16)27)25(28)22-17(11-9-15(3)4)26(31-7)21(30-6)13-19(22)32-20/h8-9,12-13,27H,10-11H2,1-7H3

HIDE SMILES / InChI

Molecular Formula	C26H30O6
Molecular Weight	438.5128
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.hmdb.ca/metabolites/HMDB36597 | https://www.ncbi.nlm.nih.gov/pubmed/25651042

3,6-DIMETHYLMANGOSTIN (Fuscaxanthone C) is a constituent of Garcinia mangostana (mangosteen). Fuscaxanthone C has shown α-glucosidase inhibitory activity.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Alpha-glucosidase MAL62 4 Target ID: CHEMBL4357 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25651042	Inhibitor 8297
Bacillus subtilis 8 Target ID: CHEMBL359 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25651042	Inhibitor 8297
Pseudomonas aeruginosa 12 Target ID: CHEMBL348 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25651042	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Bacterial infections 234 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25651042	Primary		Basic research	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Chemical constituents of Garcinia fusca: structure elucidation of eight new xanthones and their cancer chemopreventive activity.	2003 Feb	12608849
Cytotoxic constituents from Cratoxylum arborescens.	2005 Feb	15729629

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Fuscaxanthone C showed 53.8% inhibition of α-glucosidase activity at a concentration of 100 uM.

Substance Class	Chemical Created by `admin` on `Sat Dec 16 03:05:56 GMT 2023` Edited by `admin` on `Sat Dec 16 03:05:56 GMT 2023`
Record UNII	D047BK20VG
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

3,6-DIMETHYLMANGOSTIN

Common Name

English

MANGOSTIN, DIMETHYL-

Common Name

English

XANTHEN-9-ONE, 1-HYDROXY-3,6,7-TRIMETHOXY-2,8-BIS(3-METHYL-2-BUTENYL)-

Systematic Name

English

1-HYDROXY-3,6,7-TRIMETHOXY-2,8-BIS-(3-METHYL-2-BUTEN-1-YL)-9H-XANTHEN-9-ONE

Systematic Name

English

FUSCAXANTHONE C

Brand Name

English

9H-XANTHEN-9-ONE, 1-HYDROXY-3,6,7-TRIMETHOXY-2,8-BIS(3-METHYL-2-BUTEN-1-YL)-

Systematic Name

English

NSC-27594

Code

English

3,6-DIMETHYLMANGOSTIN [MI]

Common Name

English

Code System Code Type Description

PUBCHEM

231412