Piperolactam A

COC1=C(O)C2=C3C(NC(=O)C3=C1)=CC4=C2C=CC=C4

InChIKey=KBGNBPGXVKPRQI-UHFFFAOYSA-N

InChI=1S/C16H11NO3/c1-20-12-7-10-13-11(17-16(10)19)6-8-4-2-3-5-9(8)14(13)15(12)18/h2-7,18H,1H3,(H,17,19)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Condition	Potency
Progesterone receptor 61 Target ID: P06401 Gene ID: 5241.0 Gene Symbol: PGR Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/28160639	Binding Agent 1076		0.249 µM [Ki]
Estrogen receptor 72 Target ID: P03372 Gene ID: 2099.0 Gene Symbol: ESR1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/28160639	Binding Agent 1076		0.294 µM [Ki]

PubMed

Title	Date	PubMed
Pharmacoinformatics study of Piperolactam A from Piper betle root as new lead for non steroidal anti fertility drug development.	2017-04	28160639
In Vitro susceptibilities of wild and drug resistant Leishmania donovani amastigotes to piperolactam A loaded hydroxypropyl-β-cyclodextrin nanoparticles.	2016-06	26940000

Substance Class	Chemical Created by `admin` on `Wed Apr 02 06:43:50 GMT 2025` Edited by `admin` on `Wed Apr 02 06:43:50 GMT 2025`
Record UNII	CXQ3T84KLC
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

1-Hydroxy-2-methoxydibenz[cd,f]indol-4(5H)-one

Preferred Name

English

Piperolactam A

Common Name

English

Dibenz[cd,f]indol-4(5H)-one, 1-hydroxy-2-methoxy-

Systematic Name

English

14-Methoxy-15-oxidanyl-10-azatetracyclo(7.6.1.02,7.012,16)hexadeca-1(15),2,4,6,8,12(16),13-heptaen-11-one

Systematic Name

English

Code System Code Type Description

CAS

112501-42-5