TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 6

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 10:00:43 GMT 2025` Edited by `admin` on `Wed Apr 02 10:00:43 GMT 2025`
Protein Type	REGULATOR PROTEIN
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	CW4TQ5MST7
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

HEMATOPOIETIC CELL PROTEIN-TYROSINE PHOSPHATASE

Preferred Name

English

TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 6

Common Name

English

PTPN6 EXPRESSED PROTEIN

Common Name

English

PTP-1C

Common Name

English

PROTEIN-TYROSINE PHOSPHATASE 1C

Common Name

English

PROTEIN-TYROSINE PHOSPHATASE SHP-1

Common Name

English

SH-PTP1

Common Name

English

Code System Code Type Description

FDA UNII

CW4TQ5MST7

Created by admin on Wed Apr 02 10:00:43 GMT 2025 , Edited by admin on Wed Apr 02 10:00:43 GMT 2025

PRIMARY

UNIPROT

P29350

Created by admin on Wed Apr 02 10:00:43 GMT 2025 , Edited by admin on Wed Apr 02 10:00:43 GMT 2025

PRIMARY

Related Record Type Details


					OT4AQX5MLU

SC-43

AGONIST -> TARGET

Comments:

Used a SHP-?1 agonist SC-?43 to dephosphorylate STAT3 thereby suppressing oncogenic STAT3 signaling and tested it in combination with docetaxel in TNBC cells

Interaction Type:

IN-VITRO

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_64] [1_377] [1_536] [1_564]	SITE_SPECIFIC			TYROSINE O-PHOSPHATE	2R86C98KDX
AMINO_ACID_SUBSTITUTION	[1_10] [1_57]	SITE_SPECIFIC			DEXFOSFOSERINE	VI4F0K069V

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL