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APRAGLUTIDE
CVQ1IAY2G6
Investigational
General
Record Details
Names
5
Classification
3
Identifiers
5
Subunits
1
Relationships
1
Active Moiety
1
Modifications
2
Characteristic Attributes
2
APRAGLUTIDE
CVQ1IAY2G6
Investigational
General
Approval Year
Unknown
149,124
Record Details
Substance Class
Protein
Protein Type
PEPTIDE
Protein Sub Type
Record UNII
CVQ1IAY2G6
Record Status
Validated (UNII)
Record Version
19
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Names
5
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entries
Name
Type
Language
Name
Type
Language
Apraglutide [WHO-DD]
Preferred Name
English
APRAGLUTIDE
Official Name
English
L-?-Asparagine, L-histidylglycyl-L-?-aspartylglycyl-L-seryl-L-phenylalanyl-L-seryl-L-?-aspartyl-L-?-glutamyl-L-norleucyl-D-phenylalanyl-L-threonyl-L-isoleucyl-L-leucyl-L-?-aspartyl-L-leucyl-L-leucyl-L-alanyl-L-alanyl-L-arginyl-L-?-aspartyl-L-phenylalanyl
Systematic Name
English
apraglutide [INN]
Common Name
English
HIS-GLY-ASP-GLY-SER-PHE-SER-ASP-GLU-NLE-D-PHE-THR-ILE-LEU-ASP-LEU-LEU-ALA-ALA-ARG-ASP-PHE-ILE-ASN-TRP-LEU-ILE-GLN-THR-LYS-ILE-THR-ASP-NH2
Systematic Name
English
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Classification
3
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Classification Tree
Code System
Code
Classification Tree
Code System
Code
Designated
ORPHAN DRUG
Designated
Treatment of short bowel syndrome (SBS)
FDA ORPHAN DRUG
639518
Designated
ORPHAN DRUG
Designated
Prevention of acute graft-versus-host disease
FDA ORPHAN DRUG
817021
Positive
EU ORPHAN DRUG
Positive
Treatment of short bowel syndrome
EU-Orphan Drug
EU/3/18/2102
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Identifiers
5
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Code System
Code
Type
Description
Code System
Code
Type
Description
INN
10705
PRIMARY
NCI_THESAURUS
C171811
PRIMARY
SMS_ID
100000177554
PRIMARY
FDA UNII
CVQ1IAY2G6
PRIMARY
CAS
1295353-98-8
PRIMARY
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Subunits
1
Subunit 0
>SUBUNIT_0
Relationships
1
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Related Record
Type
Details
Related Record
Type
Details
I22705MV2H
GLUCAGON-LIKE PEPTIDE 2 RECEPTOR
TARGET -> AGONIST
Amount:
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Active Moiety
1
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Related Record
Type
Details
Related Record
Type
Details
CVQ1IAY2G6
APRAGLUTIDE
ACTIVE MOIETY
Amount:
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Modifications
2
Structural Modifications
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Modification Type
Location Site
Location Type
Residue Modified
Extent
Fragment Name
Fragment Approval
Modification Type
Location Site
Location Type
Residue Modified
Extent
Fragment Name
Fragment Approval
AMINO_ACID_SUBSTITUTION
[1_10]
NORLEUCINE
832C8OV84S
AMINO_ACID_SUBSTITUTION
[1_33]
Isoasparagine
L9ANT46A26
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Characteristic Attributes
2
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Name
Property Type
Amount
Referenced Substance
Defining
Parameters
References
Name
Property Type
Amount
Referenced Substance
Defining
Parameters
References
Molecular Formula
CHEMICAL
ESTIMATED
C172H264O48N46
MOL_WEIGHT:NUMBER(CALCULATED)
CHEMICAL
ESTIMATED 3760 Da (average)
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