2-BENZIMIDAZOLINONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C7H6N2O
Molecular Weight	134.1353
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O=C1NC2=CC=CC=C2N1

InChI

InChIKey=SILNNFMWIMZVEQ-UHFFFAOYSA-N

InChI=1S/C7H6N2O/c10-7-8-5-3-1-2-4-6(5)9-7/h1-4H,(H2,8,9,10)

HIDE SMILES / InChI

Molecular Formula	C7H6N2O
Molecular Weight	134.1353
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Preparation of oxime dual NK(1)/NK(2) antagonists with reduced NK(3) affinity.	2002 Sep 2	12161132
A theoretical study of substituent effects on tautomerism of 2-hydroxybenzimidazoles.	2003 Dec	12938020
Imidazopyridine/Pyrrole and hydroxybenzimidazole/pyrrole pairs for DNA minor groove recognition.	2003 May 14	12733909
Activation of human IK and SK Ca2+ -activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime).	2004 Oct 11	15471565
Computational strategies in discovering novel non-nucleoside inhibitors of HIV-1 RT.	2005 May 5	15857150
Respiratory syncytial virus fusion inhibitors. Part 3: Water-soluble benzimidazol-2-one derivatives with antiviral activity in vivo.	2006 Mar 1	16368233
DFT studies of the structure and vibrational assignments of 4-hydroxy quinazoline and 2-hydroxy benzimidazole.	2007 Apr	16870497
Respiratory syncytial virus fusion inhibitors. Part 5: Optimization of benzimidazole substitution patterns towards derivatives with improved activity.	2007 Aug 15	17576060
Synthesis and evaluation of N-3 substituted phenoxypropyl piperidine benzimidazol-2-one analogues as NOP receptor agonists with analgesic and sedative properties.	2007 Feb 15	17166723
Benzofused tricycles based on 2-quinoxalinol.	2007 Jan-Feb	17206834
Respiratory syncytial virus fusion inhibitors. Part 6: an examination of the effect of structural variation of the benzimidazol-2-one heterocycle moiety.	2007 Sep 1	17616396
Structure-activity relationships and CoMFA of N-3 substituted phenoxypropyl piperidine benzimidazol-2-one analogues as NOP receptor agonists with analgesic properties.	2008 Mar 15	18249547
Design, synthesis, and structure-activity relationships of 1,3-dihydrobenzimidazol-2-one analogues as anti-HIV agents.	2009 Aug 15	19616956
The discovery of highly potent CGRP receptor antagonists.	2009 Jan 1	19010673
Rapid access towards follow-up NOP receptor agonists using a knowledge based approach.	2009 Nov 15	19818611
1,3-Bis(hydroxy-meth-yl)benzimidazolin-2-one.	2009 Oct 17	21578330
1- or 3-(3-Amino-2-hydroxy-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones: potent, selective, and orally efficacious norepinephrine reuptake inhibitors.	2009 Sep 24	19722525
Identification of potent, highly constrained CGRP receptor antagonists.	2010 Apr 15	20299218
Slow binding-tight binding interaction between benzimidazol-2-one inhibitors and HIV-1 reverse transcriptase containing the lysine 103 to asparagine mutation.	2010 Jun	20307579
Inhibition of protein kinase C-driven nuclear factor-kappaB activation: synthesis, structure-activity relationship, and pharmacological profiling of pathway specific benzimidazole probe molecules.	2010 Jun 24	20481485
1-{[(Cyclo-hexyl-oxy)carbon-yl]-oxy}ethyl 3-{[2'-(2-ethyl-2H-tetra-zol-5-yl)biphenyl-4-yl]meth-yl}-2-oxo-2,3-dihydro-1H-benzimidazole-4-carboxyl-ate.	2010 Mar 31	21580794
1-Isopropenyl-1H-1,3-benzimidazol-2(3H)-one.	2010 May 22	21579488
Isolation and characterization of Pseudomonas sp. CBW capable of degrading carbendazim.	2010 Nov	20383655
Biodegradation of carbendazim by a novel actinobacterium Rhodococcus jialingiae djl-6-2.	2010 Oct	20833408
Computational thermochemistry of six ureas, imidazolidin-2-one, N,N'-trimethyleneurea, benzimidazolinone, parabanic acid, barbital (5,5'-diethylbarbituric acid), and 3,4,4'-trichlorocarbanilide, with an extension to related compounds.	2010 Sep 2	20681553

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:32:02 UTC 2023` Edited by `admin` on `Fri Dec 15 18:32:02 UTC 2023`
Record UNII	CV8118UZEW
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

2-BENZIMIDAZOLINONE

Systematic Name

English

2,3-DIHYDRO-2-OXO-1H-BENZIMIDAZOLE

Systematic Name

English

2-HYDROXYBENZIMIDAZOLE

Systematic Name

English

2-BENZIMIDAZOLOL

Systematic Name

English

2(3H)-BENZIMIDAZOLONE

Systematic Name

English

NSC-10383

Code

English

O-PHENYLENEUREA

Common Name

English

1,3-DIHYDRO-2H-BENZIMIDAZOLE-2-ONE

Systematic Name

English

2H-BENZIMIDAZOL-2-ONE, 1,3-DIHYDRO-

Systematic Name

English

NSC-178108

Code

English

LANSOPRAZOLE IMPURITY D [EP IMPURITY]

Common Name

English

2(3H)-OXOBENZIMIDAZOLE

Common Name

English

2-BENZIMIDAZOLONE

Systematic Name

English

BENZIMIDAZOLOL [USP IMPURITY]

Common Name

English

1H-BENZIMIDAZOL-2-OL

Common Name

English

1,3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE

Systematic Name

English

1H-BENZO(D)IMIDAZOL-2-OL

Systematic Name

English

RABEPRAZOLE SODIUM IMPURITY K [EP IMPURITY]

Common Name

English

LANSOPRAZOLE IMPURITY D

Common Name

English

N,N'-(1,2-PHENYLENEUREA)

Common Name

English

Code System Code Type Description

ECHA (EC/EINECS)

210-412-4