AFAMITRESGENE AUTOLEUCEL

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Wed Apr 02 05:57:13 GMT 2025` Edited by `admin` on `Wed Apr 02 05:57:13 GMT 2025`
Source Materials Class	ORGANISM
Source Materials Type	AUTOLOGOUS HUMAN
Source Materials State	LIVE GENETICALLY MODIFIED
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	blood
Fraction Material Type	cells
Fraction Name	cd4+ and cd8+ t cells
Record UNII	CUY18BJ7BP
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

afamitresgene autoleucel [INN]

Preferred Name

English

AFAMITRESGENE AUTOLEUCEL

Official Name

English

MAGE-A4C1032T

Code

English

AUTOLOGOUS CD4+ AND CD8+ T CELLS OBTAINED BY LEUKAPHERESIS, TRANSDUCED WITH AN HIV-DERIVED SELF-INACTIVATING (SIN) LENTIVIRAL VECTOR, ENCODING AN ENHANCED-AFFINITY T CELL RECEPTOR (TCR) SPECIFIC FOR THE HUMAN MELANOMA ANTIGEN A4 (MAGE FAMILY MEMBER A4, A

Common Name

English

AFAMITRESGENE AUTOLEUCEL [USAN]

Common Name

English

Code System Code Type Description

FDA UNII

CUY18BJ7BP

Created by admin on Wed Apr 02 05:57:13 GMT 2025 , Edited by admin on Wed Apr 02 05:57:13 GMT 2025

PRIMARY

INN

11286

Created by admin on Wed Apr 02 05:57:13 GMT 2025 , Edited by admin on Wed Apr 02 05:57:13 GMT 2025

PRIMARY

USAN

JK-54

Created by admin on Wed Apr 02 05:57:13 GMT 2025 , Edited by admin on Wed Apr 02 05:57:13 GMT 2025

PRIMARY

NCI_THESAURUS

C175738

Created by admin on Wed Apr 02 05:57:13 GMT 2025 , Edited by admin on Wed Apr 02 05:57:13 GMT 2025

PRIMARY

SMS_ID

300000009902

Created by admin on Wed Apr 02 05:57:13 GMT 2025 , Edited by admin on Wed Apr 02 05:57:13 GMT 2025

PRIMARY

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Agent Modifications

Modification Process	Modification Role	Modification Type	Amount	Fragment Name	Fragment ID
TRANSESTERIFICATION		LENTIVIRAL TRANSFECTION		AFAMITRESGENE AUTOLEUCEL VECTOR	67IL77MDD6

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
GENE_EXPRESSION VECTOR					AFAMITRESGENE AUTOLEUCEL TRANSGENE INSERT	FPE8ZTM68I

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
ANTIGEN EXPRESSED	BIOLOGICAL		CD45-RA (not present in database)
ANTIGEN EXPRESSED	BIOLOGICAL		`71FS1LH7LA` C-X-C CHEMOKINE RECEPTOR TYPE 3
ANTIGEN EXPRESSED	BIOLOGICAL		`9J9913QZ47` INTERLEUKIN-7 RECEPTOR SUBUNIT ALPHA
ANTIGEN EXPRESSED	BIOLOGICAL		`G75G5XNC3C` L-SELECTIN
ANTIGEN EXPRESSED	BIOLOGICAL		`F05Y5QQX44` T-CELL-SPECIFIC SURFACE GLYCOPROTEIN CD28
ANTIGEN EXPRESSED	BIOLOGICAL		`8R5214PE5J` CD45R0
ANTIGEN EXPRESSED	BIOLOGICAL		`P6CUL02K2A` C-C CHEMOKINE RECEPTOR TYPE 7
ANTIGEN EXPRESSED	BIOLOGICAL		`NJG4CJ69BB` CD27 ANTIGEN