Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | 2C3F6O.3H2O |
| Molecular Weight | 386.0897 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O.O.O.FC(F)(F)C(=O)C(F)(F)F.FC(F)(F)C(=O)C(F)(F)F
InChI
InChIKey=VAIZVCMDJPBJCM-UHFFFAOYSA-N
InChI=1S/2C3F6O.3H2O/c2*4-2(5,6)1(10)3(7,8)9;;;/h;;3*1H2
| Molecular Formula | H2O |
| Molecular Weight | 18.0153 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C3F6O |
| Molecular Weight | 166.0219 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Thermal chemistry and photochemistry of hexafluoroacetone on rutile TiO2(110). | 2010-07-28 |
|
| Structural optimization of photoswitch ligands for surface attachment of alpha-chymotrypsin and regulation of its surface binding. | 2010-06-18 |
|
| Identification of new non-carboxylic acid containing inhibitors of aldose reductase. | 2010-06-01 |
|
| Application of spectroscopic methods for structural analysis of chitin and chitosan. | 2010-04-29 |
|
| EPR/spin-trapping study of free radical intermediates in the photolysis of trifluoromethyl ketones with initiators. | 2010-03 |
|
| Mechanical properties of regenerated Bombyx mori silk fibers and recombinant silk fibers produced by transgenic silkworms. | 2010 |
|
| Olfactory proteins mediating chemical communication in the navel orangeworm moth, Amyelois transitella. | 2009-09-30 |
|
| Development and biological activity of a new antagonist of the pheromone of the codling moth Cydia pomonella. | 2009-09-23 |
|
| Direct construction of 1,3-diaxial diol derivatives by C-H hydroxylation. | 2009-08-20 |
|
| Synthesis of polyfluoro ketones for selective inhibition of human phospholipase A2 enzymes. | 2008-12-25 |
|
| Trifluoromethyl ketones from enolizable carboxylic acids via enediolate trifluoroacetylation/decarboxylation. | 2008-12-05 |
|
| Inhibition of cyclooxygenases 1 and 2 by the phospholipase-blocker, arachidonyl trifluoromethyl ketone. | 2008-11 |
|
| HKI 46F08, a novel potent histone deacetylase inhibitor, exhibits antitumoral activity against embryonic childhood cancer cells. | 2008-10 |
|
| Neutrophil elastase reduces secretion of secretory leukoproteinase inhibitor (SLPI) by lung epithelial cells: role of charge of the proteinase-inhibitor complex. | 2008-08-12 |
|
| Diethyl [2,2,2-trifluoro-1-phenyl-sulfonyl-amino-1-(trifluoro-meth-yl)eth-yl]phospho-nate. | 2008-08-01 |
|
| Physiologically based pharmacokinetic modeling of persistent organic pollutants for lifetime exposure assessment: a new tool in breast cancer epidemiologic studies. | 2008-07 |
|
| Synthesis of trifluoromethyl-substituted pyrazoles and 1,2,4-triazines by ring transformation of mesoionic 4-trifluoroacetyl-1,3-oxazolium-5-olates with phenylhydrazine. | 2008-04 |
|
| A novel protecting/activating strategy for beta-hydroxy acids and its use in convergent peptide synthesis. | 2008-03-21 |
|
| Screening of the active site from water by the incoming ligand triggers catalysis and inhibition in serine proteases. | 2008-03 |
|
| One-pot synthesis of 3-fluoro-4-(trifluoromethyl)quinolines from pentafluoropropen-2-ol and their molecular modification. | 2008-02-15 |
|
| Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH). | 2008-02-15 |
|
| Silklike materials constructed from sequences of Bombyx mori silk fibroin, fibronectin, and elastin. | 2008-02 |
|
| Ligand-directed immobilization of proteins through an esterase 2 fusion tag studied by atomic force microscopy. | 2008-01-04 |
|
| The cooperative effect between active site ionized groups and water desolvation controls the alteration of acid/base catalysis in serine proteases. | 2007-08-13 |
|
| Organocatalytic diastereo- and enantioselective Michael addition reactions of 5-aryl-1,3-dioxolan-4-ones. | 2007-05-24 |
|
| Hepatic sequestration of chlordecone and hexafluoroacetone evaluated by pharmacokinetic modeling. | 2007-05-05 |
|
| Complex structure of a bacterial class 2 histone deacetylase homologue with a trifluoromethylketone inhibitor. | 2007-04-01 |
|
| Conformational equilibria in formic acid and the adduct of formic acid and hexafluoroacetone, HCO2C(CF3)2OH. | 2007-03-16 |
|
| Cytotoxic activity of selected trifluoromethyl ketones against oral tumor cells. | 2007-01-05 |
|
| Hexafluoroacetone as protecting and activating reagent: new routes to amino, hydroxy, and mercapto acids and their application for peptide and glyco- and depsipeptide modification. | 2006-11 |
|
| Structural studies of a potent insect maturation inhibitor bound to the juvenile hormone esterase of Manduca sexta. | 2006-04-04 |
|
| A concise asymmetric route for the synthesis of a novel class of glucocorticoid mimetics containing a trifluoromethyl-substituted alcohol. | 2006-02 |
|
| Peptide inhibitors of Dengue virus NS3 protease. Part 1: Warhead. | 2006-01-01 |
|
| Distinctive influence of two hexafluoro solvents on the structural stabilization of Bombyx mori silk fibroin protein and its derived peptides: 13C NMR and CD studies. | 2006-01 |
|
| Use of lithium hexafluoroisopropoxide as a mild base for Horner-Wadsworth-Emmons olefination of epimerizable aldehydes. | 2005-09-15 |
|
| A new class of inhibitors of 2-arachidonoylglycerol hydrolysis and invasion of prostate cancer cells. | 2005-07-15 |
|
| Hexafluoroacetone as protecting and activating reagent: site-selective functionalization of iminodiacetic acid. | 2004-12 |
|
| Effect of a trifluoromethyl ketone on the motility of proton pump-deleted mutant of Escherichia coli strain and its wild-type. | 2004-09-17 |
|
| Effects of trifluoromethyl ketones on the motility of Proteus vulgaris. | 2004-09 |
|
| Responses of the olfactory receptor neurons of the corn stalk borer Sesamia nonagrioides to components of the pheromone blend and their inhibition by a trifluoromethyl ketone analogue of the main component. | 2004-07 |
|
| Structure and solvation of melittin in hexafluoroacetone/water. | 2004-06-15 |
|
| Conformational study of fragments of envelope proteins (gp120: 254-274 and gp41: 519-541) of HIV-1 by NMR and MD simulations. | 2004-06 |
|
| Inhibitory action of a new proton pump inhibitor, trifluoromethyl ketone derivative, against the motility of clarithromycin-susceptible and-resistant Helicobacter pylori. | 2004-06 |
|
| The low barrier hydrogen bond (LBHB) proposal revisited: the case of the Asp... His pair in serine proteases. | 2004-05-15 |
|
| Conformation of the cecropin-melittin hybrid, cecropin A(1-8)-melittin (1-18) antibacterial Peptide. | 2004-04 |
|
| The antimotility action of a trifluoromethyl ketone on some gram-negative bacteria. | 2004 |
|
| Histone deacetylase inhibitors: the Abbott experience. | 2003-11 |
|
| Design, synthesis, and biological evaluation of simplified alpha-keto heterocycle, trifluoromethyl ketone, and formyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase. | 2003-10-01 |
|
| Synthesis of a new potential tridentate anthracene ligand bearing deprotectable methoxymethoxy (OMOM) group at 1,8-positions: attempt to synthesize anionic hypervalent carbon compounds. | 2003-08-04 |
|
| Production of interferon-beta by fibroblast cells on membranes prepared with RGD-containing peptides. | 2003-06-01 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 21:51:27 GMT 2025
by
admin
on
Mon Mar 31 21:51:27 GMT 2025
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| Record UNII |
CU1NOZ8PS6
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| Record Status |
Validated (UNII)
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| Record Version |
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Preferred Name | English | ||
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DTXSID7025392
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3032602
Created by
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CU1NOZ8PS6
Created by
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13098-39-0
Created by
admin on Mon Mar 31 21:51:27 GMT 2025 , Edited by admin on Mon Mar 31 21:51:27 GMT 2025
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| Related Record | Type | Details | ||
|---|---|---|---|---|
|
ANHYDROUS->SOLVATE |
