Approval Year
| Substance Class |
Concept
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| Record UNII |
CTG26PRE5S
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| Record Status |
Validated (UNII)
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| Record Version |
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-
Download
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Code | English | ||
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Common Name | English | ||
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Code | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
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NCI_THESAURUS |
C155727
Created by
admin on Tue Apr 01 19:48:45 GMT 2025 , Edited by admin on Tue Apr 01 19:48:45 GMT 2025
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NCI_THESAURUS |
C1742
Created by
admin on Tue Apr 01 19:48:45 GMT 2025 , Edited by admin on Tue Apr 01 19:48:45 GMT 2025
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| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
300000041423
Created by
admin on Tue Apr 01 19:48:45 GMT 2025 , Edited by admin on Tue Apr 01 19:48:45 GMT 2025
|
PRIMARY | |||
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C77970
Created by
admin on Tue Apr 01 19:48:45 GMT 2025 , Edited by admin on Tue Apr 01 19:48:45 GMT 2025
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PRIMARY | NCIT | ||
|
CTG26PRE5S
Created by
admin on Tue Apr 01 19:48:45 GMT 2025 , Edited by admin on Tue Apr 01 19:48:45 GMT 2025
|
PRIMARY | |||
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1631072-93-9
Created by
admin on Tue Apr 01 19:48:45 GMT 2025 , Edited by admin on Tue Apr 01 19:48:45 GMT 2025
|
PRIMARY |
This is a non-substance concept
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
TARGET -> INHIBITOR |
Prevents FGFR ligands, such as FGF1, FGF2, FGF4, from binding to their cognate receptors, thereby inhibiting the activation of the related FGFR tyrosine kinases. Inhibition of FGFR1 by this agent may retard tumor cell proliferation and induce tumor cell death. FP-1039 may also inhibit vascular endothelial growth factor (VEGF)-induced angiogenesis. FGFR1 is a receptor tyrosine kinase upregulated in certain tumor cells and involved in tumor cellular proliferation, differentiation, angiogenesis, and survival; most ligands that bind to FGFR1 also bind to the related receptors FGFR3 and FGFR4.
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE MOIETY |
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This is a non-substance concept