ISOESTRADIOL

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C18H24O2
Molecular Weight	272.382
Optical Activity	( + )
Defined Stereocenters	5 / 5
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[C@]12CC[C@H]3[C@H](CCC4=CC(O)=CC=C34)[C@@H]1CC[C@@H]2O

InChI

InChIKey=VOXZDWNPVJITMN-FPSMNIFISA-N

InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15+,16+,17+,18+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C18H24O2
Molecular Weight	272.382
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	5 / 5
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/26716744
Curator's Comment: The description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/6479318 | https://www.ncbi.nlm.nih.gov/pubmed/3899717

Epiestradiol is an estradiol isomer with weak estrogenic activity.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Estrogen receptor alpha 134 Target ID: CHEMBL206 Sources: https://www.ncbi.nlm.nih.gov/pubmed/12077849	Agonist 2752

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2596

PubMed

Title	Date	PubMed
[Pharmacological activity of modified analogs of steroid estrogens. Racemic 8-isoestradiol].	1984-07-01	6479318

Patents

Sample Use Guides

In Vivo Use Guide

Rats were treated with 0.5mk/kg for 30 days

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 22:59:25 GMT 2025` Edited by `admin` on `Mon Mar 31 22:59:25 GMT 2025`
Record UNII	CTE8LJ0768
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

8-EPIESTRADIOL

Preferred Name

English

ISOESTRADIOL

Common Name

English

ISOESTRADIOL D-FORM [MI]

Common Name

English

(8.ALPHA.,17.BETA.)-ESTRA-1,3,5(10)-TRIENE-3,17-DIOL

Systematic Name

English

8.ALPHA.-ESTRADIOL

Common Name

English

8.ALPHA.-ESTRA-1,3,5(10)-TRIENE-3,17.BETA.-DIOL

Systematic Name

English

(+)-ISOESTRADIOL

Common Name

English

ISOESTRADIOL [MI]

Common Name

English

8-ISOESTRADIOL

Common Name

English

Code System Code Type Description

CAS

517-04-4