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Details

Stereochemistry ACHIRAL
Molecular Formula C8H7O3.Na
Molecular Weight 174.1291
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of METHYLPARABEN SODIUM

SMILES

[Na+].COC(=O)C1=CC=C([O-])C=C1

InChI

InChIKey=PESXGULMKCKJCC-UHFFFAOYSA-M
InChI=1S/C8H8O3.Na/c1-11-8(10)6-2-4-7(9)5-3-6;/h2-5,9H,1H3;/q;+1/p-1

HIDE SMILES / InChI

Molecular Formula C8H7O3
Molecular Weight 151.1394
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including https://www.fda.gov/Food/IngredientsPackagingLabeling/GRAS/SCOGS/ucm260472.htm

Methylparaben (E number E218) is preservative in the food, cosmetic, and pharmaceutical industries. It is completely absorbed through the skin or after ingestion and and it is hydrolyzed to para-hydroxybenzoic acid, and metabolites are rapidly excreted in the urine. Methylparaben is on the FDA generally regarded as safe list.

Originator

Sources: Condensation of Dimethyl-a-resorcylyl Chlorides with Phenol Ethers. Journal fuer Praktische Chemie (Leipzig), 1913, 87:403-9

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Inactive ingredient
Olanzapine

Approved Use

Olanzapine is used to treat the symptoms of psychotic conditions such as schizophrenia and bipolar disorder (manic depression) in adults and children who are at least 13 years old.

Launch Date

1996
PubMed

PubMed

TitleDatePubMed
Sorption of parabens by flexible tubings.
2001 Aug
Antibacterial effect of parabens against planktonic and biofilm Streptococcus sobrinus.
2001 Dec
ER-dependent estrogenic activity of parabens assessed by proliferation of human breast cancer MCF-7 cells and expression of ERalpha and PR.
2001 Dec
Shellac formulations to reduce epiphytic survival of coliform bacteria on citrus fruit postharvest.
2001 Nov
Larvicidal effects of mineral turpentine, low aromatic white spirits, aqueous extracts of Cassia alata, and aqueous extracts, ethanolic extracts and essential oil of betel leaf (Piper betle) on Chrysomya megacephala.
2002 Dec
Patch test results in 542 patients with suspected contact dermatitis in Turkey.
2002 Jan
Oestrogenic activity of parabens in MCF7 human breast cancer cells.
2002 Jan
The influence of model drugs on the preparation of pellets by extrusion/spheronization: II. Spheronization parameters.
2002 Jan 1
Photobleaching of compounds of the 5,10,15,20-Tetrakis(m-hydroxyphenyl)porphyrin Series (m-THPP, m-THPC, and m-THPBC).
2002 Jun 13
Estimating vapor pressure curves by thermogravimetry: a rapid and convenient method for characterization of pharmaceuticals.
2002 Sep
Determination of methylparaben in o/w emulsions by solid-phase extraction and high-performance liquid chromatography.
2003 Jan-Feb
Reversed-phase porous silica rods, an alternative approach to high-performance liquid chromatographic separation using the sequential injection chromatography technique.
2003 Oct 10
Determination of bifonazole in creams containing methyl- and propyl p-hydroxybenzoate by derivative spectrophotometric method.
2003 Sep 15
Simultaneous determination of metformin in combination with rosiglitazone by reversed-phase liquid chromatography.
2004 Feb
Effect of heat on the percutaneous absorption and skin retention of three model penetrants.
2004 Feb
Release of simulated anthrax particles from disposable respirators.
2004 Jan
Concentrations of parabens in human breast tumours.
2004 Jan-Feb
HPLC determination of estradiol, its degradation product, and preservatives in new topical formulation Estrogel HBF.
2004 Jul
Phenolic compounds and flavonoids as plant growth regulators from fruit and leaf of Vitex rotundifolia.
2004 Jul-Aug
Preventing sexual transmission of HIV: anti-HIV bioregulatory and homeostatic components of commercial sexual lubricants.
2004 Jul-Dec
Characterization of three glycosyltransferases involved in the biosynthesis of the phenolic glycolipid antigens from the Mycobacterium tuberculosis complex.
2004 Oct 8
Oestrogenic activity of p-hydroxybenzoic acid (common metabolite of paraben esters) and methylparaben in human breast cancer cell lines.
2005 Jul-Aug
Parabens: a review of epidemiology, structure, allergenicity, and hormonal properties.
2005 Jun
Propyl paraben induces potassium efflux in Escherichia coli.
2005 Jun
Decrease in skin permeation and antibacterial effect of parabens by a polymeric additive, poly(2-methacryloyloxyethyl phosphorylcholine-co-butylmetacrylate).
2005 Mar
The use of colloidal microgels as a (trans)dermal drug delivery system.
2005 Mar 23
Patents

Sample Use Guides

Methylparaben is used as a preservative in the food, cosmetic, and pharmaceutical industries. It is administered orally with food or applied topically with cosmetic products.
Route of Administration: Other
The fungistatic activity of methyl parahydroxybenzoate was determined against Candida albicans, Trichophyton rubrum, T. mentagrophytes, Microsporum audouini, Geotrichum asteroides, and Cryptococcus neoformans. Methylparaben was effective at concentrations of 150 to 350 mg/ml.
Substance Class Chemical
Created
by admin
on Sat Dec 16 04:48:05 GMT 2023
Edited
by admin
on Sat Dec 16 04:48:05 GMT 2023
Record UNII
CR6K9C2NHK
Record Status Validated (UNII)
Record Version
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Name Type Language
METHYLPARABEN SODIUM
II   USAN  
USAN  
Official Name English
SODIUM METHYL PARAHYDROXYBENZOATE
EP  
Systematic Name English
METHYLPARABEN SODIUM [II]
Common Name English
SODIUM METHYLPARABEN
INCI  
INCI  
Official Name English
SODIUM METHYL PARAHYDROXYBENZOATE [EP MONOGRAPH]
Common Name English
SODIUM METHYL PARABEN
Common Name English
METHYLPARABEN SODIUM [USAN]
Common Name English
SOLBROL M SODIUM SALT
Brand Name English
SODIUM METHYL P-HYDROXYBENZOATE ( E 219)
Common Name English
SODIUM METHYL HYDROXYBENZOATE [MART.]
Common Name English
PARIDOL MNA
Brand Name English
NS 3500S
Brand Name English
SODIUM METHYL HYDROXYBENZOATE
MART.  
Systematic Name English
NIPAGIN M SODIUM
Brand Name English
PARATEXIN MS
Brand Name English
SODIUM METHYLPARABEN [INCI]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C92608
Created by admin on Sat Dec 16 04:48:05 GMT 2023 , Edited by admin on Sat Dec 16 04:48:05 GMT 2023
EPA PESTICIDE CODE 61207
Created by admin on Sat Dec 16 04:48:05 GMT 2023 , Edited by admin on Sat Dec 16 04:48:05 GMT 2023
Code System Code Type Description
USAN
Y-26
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PRIMARY
NCI_THESAURUS
C77479
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PRIMARY
DAILYMED
CR6K9C2NHK
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PRIMARY
DRUG BANK
DBSALT002761
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PRIMARY
EPA CompTox
DTXSID1042156
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PRIMARY
EVMPD
SUB12300MIG
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PRIMARY
RXCUI
1310557
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PRIMARY RxNorm
ChEMBL
CHEMBL325372
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PRIMARY
FDA UNII
CR6K9C2NHK
Created by admin on Sat Dec 16 04:48:05 GMT 2023 , Edited by admin on Sat Dec 16 04:48:05 GMT 2023
PRIMARY
CAS
5026-62-0
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PRIMARY
PUBCHEM
23663626
Created by admin on Sat Dec 16 04:48:05 GMT 2023 , Edited by admin on Sat Dec 16 04:48:05 GMT 2023
PRIMARY
ECHA (EC/EINECS)
225-714-1
Created by admin on Sat Dec 16 04:48:05 GMT 2023 , Edited by admin on Sat Dec 16 04:48:05 GMT 2023
PRIMARY
SMS_ID
100000079320
Created by admin on Sat Dec 16 04:48:05 GMT 2023 , Edited by admin on Sat Dec 16 04:48:05 GMT 2023
PRIMARY
WIKIPEDIA
SODIUM METHYLPARABEN
Created by admin on Sat Dec 16 04:48:05 GMT 2023 , Edited by admin on Sat Dec 16 04:48:05 GMT 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE