HEXACHLOROBUTADIENE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C4Cl6
Molecular Weight	260.761
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

ClC(Cl)=C(Cl)C(Cl)=C(Cl)Cl

InChI

InChIKey=RWNKSTSCBHKHTB-UHFFFAOYSA-N

InChI=1S/C4Cl6/c5-1(3(7)8)2(6)4(9)10

HIDE SMILES / InChI

Molecular Formula	C4Cl6
Molecular Weight	260.761
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Nephrotoxicity of hexachlorobutadiene and its glutathione-derived conjugates.	1986	3764322
Urinary enzymes and protein patterns as indicators of injury to different regions of the kidney.	1987 Aug	3653576
Deacetylation and further metabolism of the mercapturic acid of hexachloro-1,3-butadiene by rat kidney cytosol in vitro.	1988	3242443
Assessment of urinary rat beta 2-microglobulin by enzyme immunoassay.	1990 Aug	2202081
The effect of haloalkene cysteine conjugates on rat renal glutathione reductase and lipoyl dehydrogenase activities.	1990 Jun 1	2360207
Effects of hexachloro-1,3- butadiene and 1,1,2,2- tetrachloroethylene on individual serum bile acids.	1992 May-Jun	1502697
Response of mouse liver coumarin 7-hydroxylase activity to hepatotoxins: dependence on strain and agent and comparison to other monooxygenases.	1993 Oct	8277979
Binding of hexachlorobutadiene to alpha 2u-globulin and its role in nephrotoxicity in rats.	1997 Dec	9439732
Alteration in the biliary and urinary excretion of acetaminophen metabolites by nephrotoxicants in rats.	1997 Mar	9144837
Tubular segment-specific biomarkers of nephrotoxicity in the rat.	2001 Oct 15	11684363
Evidence for pi-pi electron donor-acceptor interactions between pi-donor aromatic compounds and pi-acceptor sites in soil organic matter through pH effects on sorption.	2004 Aug 15	15382865
Glutathione-dependent bioactivation of haloalkanes and haloalkenes.	2004 Oct	15554237
Segmentary effects on the renal proximal tubule due to hexachloro-1,3-butadiene in rats: biomarkers related to gender.	2005 Jan-Feb	15669050
Pollution topography of chlorobenzenes and hexachlorobutadiene in sediments along the Kaohsiung coast, Taiwan--a comparison of two consecutive years' survey with statistical interpretation.	2005 Mar	15694470
Chemometrics modelling of organic contaminants in fish and sediment river samples.	2006 Dec 1	16762399
Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.	2006 Nov	16497524
Bacterial diversity of an acidic Louisiana groundwater contaminated by dense nonaqueous-phase liquid containing chloroethanes and other solvents.	2006 Oct	16958913
Environmental quality standards for water framework directive priority substances: challenges and opportunities.	2007 Apr	17477297
Exposure to hexachlorobenzene during pregnancy and children's social behavior at 4 years of age.	2007 Mar	17431497
Development of potential manufacturing routes for substituted thiophenes--preparation of halogenated 2-thiophenecarboxylic acid derivatives as building blocks for a new family of 2,6-dihaloaryl 1,2,4-triazole insecticides.	2007 Sep 4	17784956
Pharmacologic profiling of human and rat cytochrome P450 1A1 and 1A2 induction and competition.	2008 Dec	18493746
Regucalcin down-regulation in rat kidney tissue after treatment with nephrotoxicants.	2008 Nov 10	18805471
The use of redox potential to monitor biochemical HCBD dechlorination.	2009 Jun 15	19447513
Characterization of the chronic risk and hazard of hazardous air pollutants in the United States using ambient monitoring data.	2009 May	19479023
In vitro genotoxicity of polychlorinated butadienes (Cl4-Cl6).	2010 Jun 17	20417308
TTC-based risk assessment of tetrachlorobutadienes and pentachlorobutadienes--the in vitro genotoxic contaminants in ground and drinking water.	2010 Nov	20688124
Urinary biomarkers in hexachloro-1:3-butadiene-induced acute kidney injury in the female Hanover Wistar rat; correlation of α-glutathione S-transferase, albumin and kidney injury molecule-1 with histopathology and gene expression.	2011 May	21259293
Nephrotoxicity of hexachloro-1:3-butadiene in the male Hanover Wistar rat; correlation of minimal histopathological changes with biomarkers of renal injury.	2012 Jun	21905055
Correlation of histopathology, urinary biomarkers, and gene expression responses following hexachloro-1:3-butadiene-induced acute nephrotoxicity in male Hanover Wistar rats: a 28-day time course study.	2013 Jul	23136149

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:19:45 GMT 2023` Edited by `admin` on `Fri Dec 15 17:19:45 GMT 2023`
Record UNII	CQ8AAO9MO1
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

HEXACHLOROBUTADIENE

Systematic Name

English

NSC-3701

Code

English

HEXACHLORO-1,3-BUTADIENE [HSDB]

Common Name

English

HEXACHLOROBUTADIENE [IARC]

Common Name

English

PERCHLOROBUTADIENE

Systematic Name

English

HEXACHLORO-1,3-BUTADIENE

Systematic Name

English

HEXACHLOROBUTADIENE [MI]

Common Name

English

Code System Code Type Description

FDA UNII

CQ8AAO9MO1