HEXACHLOROBUTADIENE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C4Cl6
Molecular Weight	260.761
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

ClC(Cl)=C(Cl)C(Cl)=C(Cl)Cl

InChI

InChIKey=RWNKSTSCBHKHTB-UHFFFAOYSA-N

InChI=1S/C4Cl6/c5-1(3(7)8)2(6)4(9)10

HIDE SMILES / InChI

Molecular Formula	C4Cl6
Molecular Weight	260.761
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Correlation of histopathology, urinary biomarkers, and gene expression responses following hexachloro-1:3-butadiene-induced acute nephrotoxicity in male Hanover Wistar rats: a 28-day time course study.	2013-07	23136149
Nephrotoxicity of hexachloro-1:3-butadiene in the male Hanover Wistar rat; correlation of minimal histopathological changes with biomarkers of renal injury.	2012-06	21905055
Urinary biomarkers in hexachloro-1:3-butadiene-induced acute kidney injury in the female Hanover Wistar rat; correlation of α-glutathione S-transferase, albumin and kidney injury molecule-1 with histopathology and gene expression.	2011-05	21259293
TTC-based risk assessment of tetrachlorobutadienes and pentachlorobutadienes--the in vitro genotoxic contaminants in ground and drinking water.	2010-11	20688124
Development of a treatment solution for reductive dechlorination of hexachloro-1,3-butadiene in vadose zone soil.	2010-11	20383654
Determination of organic priority pollutants in sewage treatment plant effluents by gas chromatography high-resolution mass spectrometry.	2010-09-15	20801335
Persistent organic pollutants (PCB, DDT, HCH, HCB & BDE) in eels (Anguilla anguilla) in Scotland: current levels and temporal trends.	2010-07	20471146
In vitro genotoxicity of polychlorinated butadienes (Cl4-Cl6).	2010-06-17	20417308
Protective effect of pomegranate seed oil on hexachlorobutadiene-induced nephrotoxicity in rat kidneys.	2010-06	20486845
Kidney injury molecule-1 expression in rat proximal tubule after treatment with segment-specific nephrotoxicants: a tool for early screening of potential kidney toxicity.	2010-04	20305092
Evaluation of aging influence on renal toxicity caused by segment-specific nephrotoxicants of the proximal tubule in rat.	2010-03	19742859
Destruction of trichloroethylene during hydration of calcium oxide.	2010-02-15	19800167
[Health risk analysis of VOC/SVOC contaminated soil in an abandoned chemical plant].	2010-02	20391709
The use of redox potential to monitor biochemical HCBD dechlorination.	2009-06-15	19447513
Characterization of the chronic risk and hazard of hazardous air pollutants in the United States using ambient monitoring data.	2009-05	19479023
Pharmacologic profiling of human and rat cytochrome P450 1A1 and 1A2 induction and competition.	2008-12	18493746
Regucalcin down-regulation in rat kidney tissue after treatment with nephrotoxicants.	2008-11-10	18805471
Identification and degradation characterization of hexachlorobutadiene degrading strain Serratia marcescens HL1.	2008-10	18337093
Low-level exposure to multiple chemicals: reason for human health concerns?	2007-12	18174958
Occurrence and potential human-health relevance of volatile organic compounds in drinking water from domestic wells in the United States.	2007-11	18007981
Development of potential manufacturing routes for substituted thiophenes--preparation of halogenated 2-thiophenecarboxylic acid derivatives as building blocks for a new family of 2,6-dihaloaryl 1,2,4-triazole insecticides.	2007-09-04	17784956
Environmental quality standards for water framework directive priority substances: challenges and opportunities.	2007-04	17477297
Description of industrial pollution in Spain.	2007-03-21	17376231
Exposure to hexachlorobenzene during pregnancy and children's social behavior at 4 years of age.	2007-03	17431497
Renal proximal tubule segment-specific nephrotoxicity: an overview on biomarkers and histopathology.	2007-02	17366321
Chemometrics modelling of organic contaminants in fish and sediment river samples.	2006-12-01	16762399
Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.	2006-11	16497524
Bacterial diversity of an acidic Louisiana groundwater contaminated by dense nonaqueous-phase liquid containing chloroethanes and other solvents.	2006-10	16958913
Mild tubular damage induces calcium oxalate crystalluria in a model of subtle hyperoxaluria: Evidence that a second hit is necessary for renal lithogenesis.	2006-08	16790510
Organochlorine and organophosphorous pesticide residues in the Ouémé River catchment in the Republic of Bénin.	2006-07	16533533
New organochlorine contaminants and metabolites in plasma and eggs of glaucous gulls (Larus hyperboreus) from the Norwegian Arctic.	2005-10	16268150
Glutamine transaminase K intranephron localization in rats determined by urinary excretion after treatment with segment-specific nephrotoxicants.	1998-10-09	9765069
Binding of hexachlorobutadiene to alpha 2u-globulin and its role in nephrotoxicity in rats.	1997-12	9439732
Alteration in the biliary and urinary excretion of acetaminophen metabolites by nephrotoxicants in rats.	1997-03	9144837
Intranephron distribution of cysteine S-conjugate beta-lyase activity and its implication for hexachloro-1,3-butadiene-induced nephrotoxicity in rats.	1997	9049049
Assessment of the role of glutathione conjugation in the protection afforded by anethol dithiolthione against hexachloro-1,3-butadiene-induced nephrotoxicity.	1996-07	8685901
Bone marrow and renal injury associated with haloalkene cysteine conjugates in calves.	1996	8870953
The sulfoxidation of the hexachlorobutadiene metabolite N-acetyl-S-(1,2,3,4,4-pentachlorobutadienyl)-L-cysteine is catalyzed by human cytochrome P450 3A enzymes.	1995-10-01	8555406
Enhanced hexachloro-1:3-butadiene nephrotoxicity in rats with a preexisting adriamycin-induced nephrotic syndrome.	1995-05-01	7659954
Response of mouse liver coumarin 7-hydroxylase activity to hepatotoxins: dependence on strain and agent and comparison to other monooxygenases.	1993-10	8277979
Assessment of urinary rat beta 2-microglobulin by enzyme immunoassay.	1990-08	2202081
The effect of haloalkene cysteine conjugates on rat renal glutathione reductase and lipoyl dehydrogenase activities.	1990-06-01	2360207
Cysteine conjugate beta-lyase of rat kidney cytosol: characterization, immunocytochemical localization, and correlation with hexachlorobutadiene nephrotoxicity.	1989-04	2711386
Investigations into the biochemical effects of region-specific nephrotoxins.	1989-02	2918855
The use of renal cortical slices from the Fischer 344 rat as an in vitro model to evaluate nephrotoxicity.	1988-07	2905310
Deacetylation and further metabolism of the mercapturic acid of hexachloro-1,3-butadiene by rat kidney cytosol in vitro.	1988	3242443
Urinary enzymes and protein patterns as indicators of injury to different regions of the kidney.	1987-08	3653576
Nephrotoxicity of hexachlorobutadiene and its glutathione-derived conjugates.	1986	3764322
Distribution of 5'-nucleotidase in the tissues of sheep and the effect of kidney and liver lesions on the activity of the enzyme in plasma and urine.	1985-07	2863857
Role of microsomal and cytosolic glutathione S-transferases in the conjugation of hexachloro-1:3-butadiene and its possible relevance to toxicity.	1984-01	6694103

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:44:45 GMT 2025` Edited by `admin` on `Mon Mar 31 18:44:45 GMT 2025`
Record UNII	CQ8AAO9MO1
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

HEXACHLOROBUTADIENE

Systematic Name

English

HEXACHLORO-1,3-BUTADIENE

Preferred Name

English

NSC-3701

Code

English

HEXACHLORO-1,3-BUTADIENE [HSDB]

Common Name

English

HEXACHLOROBUTADIENE [IARC]

Common Name

English

PERCHLOROBUTADIENE

Systematic Name

English

HEXACHLOROBUTADIENE [MI]

Common Name

English

Code System Code Type Description

FDA UNII

CQ8AAO9MO1