Details
Stereochemistry | ACHIRAL |
Molecular Formula | 4Cl.Hf |
Molecular Weight | 320.3 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[Cl-].[Cl-].[Cl-].[Cl-].[Hf+4]
InChI
InChIKey=PDPJQWYGJJBYLF-UHFFFAOYSA-J
InChI=1S/4ClH.Hf/h4*1H;/q;;;;+4/p-4
Molecular Formula | ClH |
Molecular Weight | 36.461 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | Hf |
Molecular Weight | 178.49 |
Charge | 4 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Hafnium oxide is a radio enhancer; its nanoparticles (NBTXR3) were designed for high dose energy deposition within cancer cells when exposed to ionizing radiation. When activated by radiotherapy (RT), NBTXR3 allows for a higher energy deposit than RT alone, yielding an increased tumoral cell death. Nanocrystals of hafnium oxide are under investigation in phase II/III in patients with locally advanced soft tissue sarcoma (STS) of the extremity and trunk wall. In addition, NBTXR3, nanoparticles are being studied in phase I/II in patients with head and neck cancer; liver cancer; prostate cancer and rectal cancer.
Originator
Approval Year
Sample Use Guides
In Vivo Use Guide
Sources: https://clinicaltrials.gov/ct2/show/NCT02379845
One intratumor implantation by injection of NBTXR3 (Hafnium oxide nanocrystals) + Radiotherapy
Route of Administration:
Other
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 10:46:10 GMT 2023
by
admin
on
Sat Dec 16 10:46:10 GMT 2023
|
Record UNII |
CNZ9V5JM5H
|
Record Status |
Validated (UNII)
|
Record Version |
|
-
Download
Name | Type | Language | ||
---|---|---|---|---|
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English |
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
CNZ9V5JM5H
Created by
admin on Sat Dec 16 10:46:10 GMT 2023 , Edited by admin on Sat Dec 16 10:46:10 GMT 2023
|
PRIMARY | |||
|
37715
Created by
admin on Sat Dec 16 10:46:10 GMT 2023 , Edited by admin on Sat Dec 16 10:46:10 GMT 2023
|
PRIMARY | |||
|
DTXSID0065513
Created by
admin on Sat Dec 16 10:46:10 GMT 2023 , Edited by admin on Sat Dec 16 10:46:10 GMT 2023
|
PRIMARY | |||
|
Hafnium chloride
Created by
admin on Sat Dec 16 10:46:10 GMT 2023 , Edited by admin on Sat Dec 16 10:46:10 GMT 2023
|
PRIMARY | |||
|
m5893
Created by
admin on Sat Dec 16 10:46:10 GMT 2023 , Edited by admin on Sat Dec 16 10:46:10 GMT 2023
|
PRIMARY | Merck Index | ||
|
13499-05-3
Created by
admin on Sat Dec 16 10:46:10 GMT 2023 , Edited by admin on Sat Dec 16 10:46:10 GMT 2023
|
PRIMARY | |||
|
236-826-5
Created by
admin on Sat Dec 16 10:46:10 GMT 2023 , Edited by admin on Sat Dec 16 10:46:10 GMT 2023
|
PRIMARY |