Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C23H25F3N4O5.CH4O3S |
| Molecular Weight | 590.569 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CS(O)(=O)=O.CN1C=C(N=C1C2=CC=C(OCC(O)CNCCOC3=CC(C(N)=O)=C(O)C=C3)C=C2)C(F)(F)F
InChI
InChIKey=VFPOVCXWKBYDNF-UHFFFAOYSA-N
InChI=1S/C23H25F3N4O5.CH4O3S/c1-30-12-20(23(24,25)26)29-22(30)14-2-4-16(5-3-14)35-13-15(31)11-28-8-9-34-17-6-7-19(32)18(10-17)21(27)33;1-5(2,3)4/h2-7,10,12,15,28,31-32H,8-9,11,13H2,1H3,(H2,27,33);1H3,(H,2,3,4)
| Molecular Formula | C23H25F3N4O5 |
| Molecular Weight | 494.4636 |
| Charge | 0 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
| Molecular Formula | CH4O3S |
| Molecular Weight | 96.106 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Catecholamines relax detrusor through beta 2-adrenoceptors in mouse and beta 3-adrenoceptors in man. | 2009-01 |
|
| Histamine augments beta2-adrenoceptor-induced cyclic AMP accumulation in human prostate cancer cells DU-145 independently of known histamine receptors. | 2007-03-15 |
|
| Recruitment of functionally active heart beta2-adrenoceptors in the initial phase of endotoxic shock in pithed rats. | 2006-11 |
|
| Agonist-specific activation of the beta2-adrenoceptor/Gs-protein and beta2-adrenoceptor/Gi-protein pathway in adult rat ventricular cardiomyocytes. | 2006-04 |
|
| Carvedilol blocks beta2- more than beta1-adrenoceptors in human heart. | 2006-01 |
|
| Functional characterization of the beta-adrenergic receptor subtypes expressed by CA1 pyramidal cells in the rat hippocampus. | 2005-08 |
|
| The selectivity of beta-adrenoceptor antagonists at the human beta1, beta2 and beta3 adrenoceptors. | 2005-02 |
|
| Comparative pharmacology of human beta-adrenergic receptor subtypes--characterization of stably transfected receptors in CHO cells. | 2004-02 |
|
| Function of beta1-adrenoceptors and mRNA expression of beta1- and beta2-adrenoceptors in guinea-pig esophagus. | 2003-07-18 |
|
| Agonist actions of "beta-blockers" provide evidence for two agonist activation sites or conformations of the human beta1-adrenoceptor. | 2003-06 |
|
| Beta-adrenergic receptor blockade modulates Bcl-X(S) expression and reduces apoptosis in failing myocardium. | 2003-05 |
|
| Functional and molecular characterization of beta-adrenoceptors in the internal anal sphincter. | 2003-05 |
|
| Regeneration of cardiomyocytes from bone marrow: Use of mesenchymal stem cell for cardiovascular tissue engineering. | 2003-03 |
|
| Beta 1-adrenoceptor selectivity of nebivolol and bisoprolol. A comparison of [3H]CGP 12.177 and [125I]iodocyanopindolol binding studies. | 2003-01-26 |
|
| Physiological antagonism between ventricular beta 1-adrenoceptors and alpha 1-adrenoceptors but no evidence for beta 2- and beta 3-adrenoceptor function in murine heart. | 2002-05 |
|
| Bone marrow-derived regenerated cardiomyocytes (CMG Cells) express functional adrenergic and muscarinic receptors. | 2002-01-22 |
|
| Comparison of the affinity of beta-blockers for two states of the beta 1-adrenoceptor in ferret ventricular myocardium. | 2002-01 |
|
| Constitutive activity of the human beta(1)-adrenergic receptor in beta(1)-receptor transgenic mice. | 2001-10 |
|
| beta(1)-Adrenoceptors compensate for beta(3)-adrenoceptors in ileum from beta(3)-adrenoceptor knock-out mice. | 2001-01 |
|
| Opposing effects of beta(1)- and beta(2)-adrenergic receptors on cardiac myocyte apoptosis : role of a pertussis toxin-sensitive G protein. | 1999-11-30 |
|
| Potent and selective human beta(3)-adrenergic receptor antagonists. | 1999-08 |
|
| Selective activation of beta3-adrenoceptors by octopamine: comparative studies in mammalian fat cells. | 1999-04 |
|
| LK 204-545, a highly selective beta1-adrenoceptor antagonist at human beta-adrenoceptors. | 1999-02-19 |
|
| SR59230A blocks beta3-adrenoceptor-linked modulation of upcoupling protein-1 and leptin in rat brown adipocytes. | 1998-07-03 |
|
| Carazolol: a potent, selective beta 3-adrenoceptor agonist. | 1995-11-30 |
|
| Pre- and postganglionic stimulation-induced noradrenaline overflow is markedly facilitated by a prejunctional beta 2-adrenoceptor-mediated control mechanism in the pithed rat. | 1994-06 |
|
| Atypical beta-adrenergic receptor in 3T3-F442A adipocytes. Pharmacological and molecular relationship with the human beta 3-adrenergic receptor. | 1991-10-25 |
|
| The receptor binding profile of the new antihypertensive agent nebivolol and its stereoisomers compared with various beta-adrenergic blockers. | 1988-12 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 21:51:35 GMT 2025
by
admin
on
Mon Mar 31 21:51:35 GMT 2025
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| Record UNII |
CNU8DA2K9J
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| Record Status |
Validated (UNII)
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| Record Version |
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DTXSID90434017
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105737-62-0
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10008573
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admin on Mon Mar 31 21:51:35 GMT 2025 , Edited by admin on Mon Mar 31 21:51:35 GMT 2025
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CNU8DA2K9J
Created by
admin on Mon Mar 31 21:51:35 GMT 2025 , Edited by admin on Mon Mar 31 21:51:35 GMT 2025
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