Ubletamig

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 05:46:34 GMT 2025` Edited by `admin` on `Wed Apr 02 05:46:34 GMT 2025`
Protein Type	BISPECIFIC ANTIBODY
Protein Sub Type	IGG4\|KAPPA
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	CN0DU4MQE0
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Ubletamig

Official Name

English

H-gamma4 heavy chain anti-MUC16 Homo sapiens (1-455) [VH (Homo sapiens IGHV3-49*04 (93.9%) -(IGHD) -IGHJ6*04 (90.0%) K120>R (121), CDR-IMGT [8.10.20] (26-33.51-60.99-118)) (1-129)-Homo sapiens IGHG4*01 nG4m(a) CH2 L92, 12-G4v5 h P10, 6-G4v7 CH2 delE1.4,

Preferred Name

English

Immunoglobulin G4 [237-proline,242-proline,243-valine,244-alanine,de-245-glycine], anti-(human mucin-16) (human monoclonal REGN5668 ?4-chain), disulfide with human monoclonal REGN5668 ?-chain, (235?228?),(238?231?)-bis(disulfide) with immunoglobulin G4 [

Common Name

English

ubletamig [INN]

Common Name

English

immunoglobulin (H-gamma4_L-kappa)_( H-gamma4_L-kappa), anti-[Homo sapiens MUC16 (mucin 16, MUC-16, cancer antigen 125, CA125)] and anti-[Homo sapiens CD28 (T cell specific surface glycoprotein CD28, TP44)], Homo sapiens monoclonal antibody, bispecific, b

Common Name

English

Code System Code Type Description

INN

13410

Created by admin on Wed Apr 02 05:46:34 GMT 2025 , Edited by admin on Wed Apr 02 05:46:34 GMT 2025

PRIMARY

FDA UNII

CN0DU4MQE0

Created by admin on Wed Apr 02 05:46:34 GMT 2025 , Edited by admin on Wed Apr 02 05:46:34 GMT 2025

PRIMARY

CAS

3008247-27-3

Created by admin on Wed Apr 02 05:46:34 GMT 2025 , Edited by admin on Wed Apr 02 05:46:34 GMT 2025

PRIMARY

From	To
1_22	1_98
1_156	1_212
1_143	3_215
1_235	2_228
1_238	2_231
1_269	1_329
1_375	1_433
2_22	2_95
2_149	2_205
2_136	4_215
2_262	2_322
2_368	2_426
3_23	3_89
3_135	3_195
4_23	4_89
4_135	4_195

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_305
N	2_298

Related Record Type Details


					45047SF2ZS

CA-125

TARGET->LIGAND

Amount:


					F05Y5QQX44

T-CELL-SPECIFIC SURFACE GLYCOPROTEIN CD28

TARGET->LIGAND

Amount:

Related Record Type Details


					CN0DU4MQE0

Ubletamig

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[2_1]	N-TERMINUS	Q	PIDOLIC ACID	SZB83O1W42
AMINO ACID REMOVAL	[1_455]	C-TERMINUS	K	LYSINE	K3Z4F929H6
AMINO ACID REMOVAL	[2_448]	C-TERMINUS	K	LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL