YM-53601 free base

F\C(COC1=CC2=C(C=C1)C3=C(N2)C=CC=C3)=C4\CN5CCC4CC5

InChIKey=XNDCPFTULXRWQH-HNENSFHCSA-N

InChI=1S/C21H21FN2O/c22-19(18-12-24-9-7-14(18)8-10-24)13-25-15-5-6-17-16-3-1-2-4-20(16)23-21(17)11-15/h1-6,11,14,23H,7-10,12-13H2/b19-18-

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Condition	Potency
Squalene synthase 1 Target ID: P37268 Gene ID: 2222.0 Gene Symbol: FDFT1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/10960070	Inhibitor 8504		79.0 nM [IC50]
Squalene synthetase 2 Target ID: CHEMBL3338 Sources: https://www.ncbi.nlm.nih.gov/pubmed/12359639	Inhibitor 8504

PubMed

Title	Date	PubMed
Effect of YM-53601, a novel squalene synthase inhibitor, on the clearance rate of plasma LDL and VLDL in hamsters.	2002-10	12359639

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:56:06 GMT 2025` Edited by `admin` on `Mon Mar 31 21:56:06 GMT 2025`
Record UNII	CM6NLS5FVJ
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

2-[(2E)-2-(1-azabicyclo[2.2.2]octan-3-ylidene)-2-fluoroethoxy]-9H-carbazole

Preferred Name

English

YM-53601 free base

Common Name

English

3-(((2E)-2-(1-AZABICYCLO(2.2.2)OCT-3-YLIDENE)-2-FLUOROETHYL)OXY)-9H-CARBAZOLE

Systematic Name

English

9H-Carbazole, 2-[2-(1-azabicyclo[2.2.2]oct-3-ylidene)-2-fluoroethoxy]-, (E)-

Systematic Name

English

Code System Code Type Description

CAS

182959-28-0