DESMETHYLSERTRALINE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C16H15Cl2N
Molecular Weight	292.203
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

N[C@H]1CC[C@@H](C2=CC(Cl)=C(Cl)C=C2)C3=C1C=CC=C3

InChI

InChIKey=SRPXSILJHWNFMK-ZBEGNZNMSA-N

InChI=1S/C16H15Cl2N/c17-14-7-5-10(9-15(14)18)11-6-8-16(19)13-4-2-1-3-12(11)13/h1-5,7,9,11,16H,6,8,19H2/t11-,16-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C16H15Cl2N
Molecular Weight	292.203
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

PubMed

Title	Date	PubMed
Pharmacokinetics of sertraline in relation to genetic polymorphism of CYP2C19.	2001 Jul	11452243
Platelet inhibition by sertraline and N-desmethylsertraline: a possible missing link between depression, coronary events, and mortality benefits of selective serotonin reuptake inhibitors.	2001 May	11394937
Sertraline-induced hypoglycemia.	2001 Nov	11724085
Maternal sertraline treatment and serotonin transport in breast-feeding mother-infant pairs.	2001 Oct	11578995
The selective serotonin reuptake inhibitor sertraline: its profile and use in psychiatric disorders.	2001 Spring	11420570
[Postmortem distribution of sertraline and desmethylsertraline in a fatality].	2002 Jul-Aug	12365335
Inhibition of P-glycoprotein by newer antidepressants.	2003 Apr	12649369
Novel N6-substituted adenosine 5'-N-methyluronamides with high selectivity for human adenosine A3 receptors reduce ischemic myocardial injury.	2003 Dec	12919933
The pharmacokinetics of sertraline excretion into human breast milk: determinants of infant serum concentrations.	2003 Jan	12590627
Effects of an educational compliance enhancement programme and therapeutic drug monitoring on treatment adherence in depressed patients managed by general practitioners.	2003 Nov	14571155
Relationship between release of platelet/endothelial biomarkers and plasma levels of sertraline and N-desmethylsertraline in acute coronary syndrome patients receiving SSRI treatment for depression.	2005 Jun	15932816
Postpartum depression: a randomized trial of sertraline versus nortriptyline.	2006 Aug	16855451
Determination of sertraline and N-desmethylsertraline in human plasma by CE with LIF detection.	2007 Jun	17450537
Sertraline and its metabolite desmethylsertraline, but not bupropion or its three major metabolites, have high affinity for P-glycoprotein.	2008 Feb	18239278
Partial compliance as determined from plasma levels of sertraline and its metabolite in depressed patients in primary care.	2010 Dec	21057244

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 08:34:22 UTC 2023` Edited by `admin` on `Sat Dec 16 08:34:22 UTC 2023`
Record UNII	CJJ71O9BE8
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DESMETHYLSERTRALINE

Common Name

English

1-NAPHTHALENAMINE, 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-, (1S,4S)-

Systematic Name

English

NORSERTRALINE

Common Name

English

CP-53261

Code

English

N-DESMETHYLSERTRALINE

Common Name

English

Code System Code Type Description

PUBCHEM

114743