Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C16H15Cl2N |
| Molecular Weight | 292.203 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
N[C@H]1CC[C@@H](C2=CC(Cl)=C(Cl)C=C2)C3=C1C=CC=C3
InChI
InChIKey=SRPXSILJHWNFMK-ZBEGNZNMSA-N
InChI=1S/C16H15Cl2N/c17-14-7-5-10(9-15(14)18)11-6-8-16(19)13-4-2-1-3-12(11)13/h1-5,7,9,11,16H,6,8,19H2/t11-,16-/m0/s1
| Molecular Formula | C16H15Cl2N |
| Molecular Weight | 292.203 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Inhibition of P-glycoprotein by newer antidepressants. | 2003 Apr |
|
| Novel N6-substituted adenosine 5'-N-methyluronamides with high selectivity for human adenosine A3 receptors reduce ischemic myocardial injury. | 2003 Dec |
|
| Serum disposition of sertraline, N-desmethylsertraline and paroxetine: a pharmacokinetic evaluation of repeated drug concentration measurements during 6 months of treatment for major depression. | 2004 Jul |
|
| Compliance with SSRI medication during 6 months of treatment for major depression: an evaluation by determination of repeated serum drug concentrations. | 2004 Nov 1 |
|
| Development of a solid phase extraction for 13 'new' generation antidepressants and their active metabolites for gas chromatographic-mass spectrometric analysis. | 2005 Dec 9 |
|
| Determination of select antidepressants in fish from an effluent-dominated stream. | 2005 Feb |
|
| Relationship between release of platelet/endothelial biomarkers and plasma levels of sertraline and N-desmethylsertraline in acute coronary syndrome patients receiving SSRI treatment for depression. | 2005 Jun |
|
| Serum concentrations of sertraline and N-desmethyl sertraline in relation to CYP2C19 genotype in psychiatric patients. | 2008 Dec |
|
| Determination of basic antidepressants and their N-desmethyl metabolites in raw sewage and wastewater using solid-phase extraction and liquid chromatography-tandem mass spectrometry. | 2008 Jul 15 |
|
| Determination of antidepressants in human postmortem blood, brain tissue, and hair using gas chromatography-mass spectrometry. | 2009 Nov |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:34:22 GMT 2023
by
admin
on
Sat Dec 16 08:34:22 GMT 2023
|
| Record UNII |
CJJ71O9BE8
|
| Record Status |
Validated (UNII)
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| Record Version |
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-
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| Code System | Code | Type | Description | ||
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114743
Created by
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CJJ71O9BE8
Created by
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SUB112492
Created by
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DB14071
Created by
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Desmethylsertraline
Created by
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87857-41-8
Created by
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DTXSID60236666
Created by
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100000142067
Created by
admin on Sat Dec 16 08:34:23 GMT 2023 , Edited by admin on Sat Dec 16 08:34:23 GMT 2023
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| Related Record | Type | Details | ||
|---|---|---|---|---|
|
PARENT -> METABOLITE LESS ACTIVE |
