Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | Ga |
| Molecular Weight | 69.723 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Ga]
InChI
InChIKey=PHMDYZQXPPOZDG-UHFFFAOYSA-N
InChI=1S/Ga.3H
| Molecular Formula | Ga |
| Molecular Weight | 69.723 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Gallium (Ga) is an element. It is a soft, slivery blue metal that becomes liquid (and silvery white) above room temperature. Gallium has been investigated for its anticancer properties since it was discovered that 67Ga(III) citrate injected in tumor-bearing animals localizes to tumor sites. Gallium has been investigated for treatment in multiple types of cancer (bladder cancer, lymphoma, multiple myeloma, paget's disease, and prostate cancer). Different generations of gallium salt are being evaluated for their antitumor efficacy and are in preclinical or clinical development. Gallium might also display antimicrobial activity, and is thought to disrupt iron homeostasis in certain bacteria and fungi.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Uptake of aluminum and gallium into tissues of the rat: influence of antibody against the transferrin receptor. | 1998 Apr-May |
|
| Preclinical characterization of anticancer gallium(III) complexes: solubility, stability, lipophilicity and binding to serum proteins. | 2006 Nov |
|
| Gallium uptake by transferrin and interaction with receptor 1. | 2007 Jan |
|
| Organogallium(III) complexes as apoptosis promoting anticancer agents for head and neck squamous cell carcinoma (HNSCC) cell lines. | 2011 Feb |
| Substance Class |
Chemical
Created
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admin
on
Edited
Fri Dec 15 18:53:41 UTC 2023
by
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on
Fri Dec 15 18:53:41 UTC 2023
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| Record UNII |
CH46OC8YV4
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| Record Status |
Validated (UNII)
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| Record Version |
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NCI_THESAURUS |
C637
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DSLD |
3352 (Number of products:30)
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C66798
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100000125930
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5360835
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1310124
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7440-55-3
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D005708
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SUB32650
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CH46OC8YV4
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CH46OC8YV4
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Gallium
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6956
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DTXSID401029758
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49631
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m5646
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231-163-8
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