Details
Stereochemistry | ACHIRAL |
Molecular Formula | C14H19N4.Cl.H2O4S |
Molecular Weight | 376.859 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[Cl-].OS(O)(=O)=O.CCCC1=NC=C(C[N+]2=CC=CC=C2C)C(N)=N1
InChI
InChIKey=PPMWMVFUPFMJPD-UHFFFAOYSA-M
InChI=1S/C14H19N4.ClH.H2O4S/c1-3-6-13-16-9-12(14(15)17-13)10-18-8-5-4-7-11(18)2;;1-5(2,3)4/h4-5,7-9H,3,6,10H2,1-2H3,(H2,15,16,17);1H;(H2,1,2,3,4)/q+1;;/p-1
Molecular Formula | Cl |
Molecular Weight | 35.453 |
Charge | -1 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | C14H19N4 |
Molecular Weight | 243.3275 |
Charge | 1 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | H2O4S |
Molecular Weight | 98.078 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionSources: http://www.ema.europa.eu/docs/en_GB/document_library/Maximum_Residue_Limits_-_Report/2009/11/WC500010566.pdfhttps://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=49295a3c-eb73-4832-a8a3-5c1967accb4d | https://www.ncbi.nlm.nih.gov/pubmed/11502555Curator's Comment: Description was created based on several sources, including
http://scienceinternational.com/fulltext/?doi=sciintl.2013.261.265 | http://www.merckvetmanual.com/poultry/coccidiosis/overview-of-coccidiosis-in-poultry
Sources: http://www.ema.europa.eu/docs/en_GB/document_library/Maximum_Residue_Limits_-_Report/2009/11/WC500010566.pdfhttps://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=49295a3c-eb73-4832-a8a3-5c1967accb4d | https://www.ncbi.nlm.nih.gov/pubmed/11502555
Curator's Comment: Description was created based on several sources, including
http://scienceinternational.com/fulltext/?doi=sciintl.2013.261.265 | http://www.merckvetmanual.com/poultry/coccidiosis/overview-of-coccidiosis-in-poultry
Amprolium Hydrochloride is a broad spectrum, potent coccidiostat (anti-protozoal) used for the treatment and prevention of Coccidiosis in cattle, goats, sheep, and poultry (chicken and turkey) in veterinary. Amprolium probably acts by inhibiting thiamine uptake by parasites and thus creates disorders in the metabolism of parasites.
CNS Activity
Sources: http://www.ema.europa.eu/docs/en_GB/document_library/Maximum_Residue_Limits_-_Report/2009/11/WC500010566.pdf
Curator's Comment: Amprolium is brain penetrant in animals. No human data available.
Originator
Sources: https://www.google.com/patents/US3020277
Curator's Comment: # Merck & Co Inc
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL612854 |
|||
Target ID: thiamine uptake Sources: https://www.ncbi.nlm.nih.gov/pubmed/11502555 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Curative | CORID Approved UseUnknown |
Sample Use Guides
Amprolium is a coccidiostat which is used for the treatment and prevention of coccidiosis in chickens, including laying hens, and turkeys. For treatment, it is administered in the drinking water at a concentration of 120 to 240 mg/l, or in the feed at a concentration of 125 mg/kg feed, for 5 to 7 days. For prevention of re-infection, it is administered in the drinking water at a concentration of 60 mg/l for 1 to 2 weeks.
Route of Administration:
Oral
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 19:28:55 GMT 2023
by
admin
on
Sat Dec 16 19:28:55 GMT 2023
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Record UNII |
CG9CW682NC
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Record Status |
Validated (UNII)
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Record Version |
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admin on Sat Dec 16 19:28:55 GMT 2023 , Edited by admin on Sat Dec 16 19:28:55 GMT 2023
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