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Details

Stereochemistry ACHIRAL
Molecular Formula C14H19N4.Cl.H2O4S
Molecular Weight 376.859
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of AMPROLIUM SULFATE

SMILES

[Cl-].OS(O)(=O)=O.CCCC1=NC=C(C[N+]2=CC=CC=C2C)C(N)=N1

InChI

InChIKey=PPMWMVFUPFMJPD-UHFFFAOYSA-M
InChI=1S/C14H19N4.ClH.H2O4S/c1-3-6-13-16-9-12(14(15)17-13)10-18-8-5-4-7-11(18)2;;1-5(2,3)4/h4-5,7-9H,3,6,10H2,1-2H3,(H2,15,16,17);1H;(H2,1,2,3,4)/q+1;;/p-1

HIDE SMILES / InChI

Molecular Formula Cl
Molecular Weight 35.453
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C14H19N4
Molecular Weight 243.3275
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula H2O4S
Molecular Weight 98.078
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: Description was created based on several sources, including http://scienceinternational.com/fulltext/?doi=sciintl.2013.261.265 | http://www.merckvetmanual.com/poultry/coccidiosis/overview-of-coccidiosis-in-poultry

Amprolium Hydrochloride is a broad spectrum, potent coccidiostat (anti-protozoal) used for the treatment and prevention of Coccidiosis in cattle, goats, sheep, and poultry (chicken and turkey) in veterinary. Amprolium probably acts by inhibiting thiamine uptake by parasites and thus creates disorders in the metabolism of parasites.

CNS Activity

Curator's Comment: Amprolium is brain penetrant in animals. No human data available.

Originator

Curator's Comment: # Merck & Co Inc

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
CORID

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Patents

Sample Use Guides

Amprolium is a coccidiostat which is used for the treatment and prevention of coccidiosis in chickens, including laying hens, and turkeys. For treatment, it is administered in the drinking water at a concentration of 120 to 240 mg/l, or in the feed at a concentration of 125 mg/kg feed, for 5 to 7 days. For prevention of re-infection, it is administered in the drinking water at a concentration of 60 mg/l for 1 to 2 weeks.
Route of Administration: Oral
Amprolium hydrochloride significantly decreased K. septempunctata spore viability at a concentration of 920 μg/mL. Amprolium exerts anticoccidial activity against Eimeria tenella at 100 μg/ml.
Substance Class Chemical
Created
by admin
on Sat Dec 16 19:28:55 GMT 2023
Edited
by admin
on Sat Dec 16 19:28:55 GMT 2023
Record UNII
CG9CW682NC
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
AMPROLIUM SULFATE
Common Name English
Pyridinium, 1-[(4-amino-2-propyl-5-pyrimidinyl)methyl]-2-methyl-, chloride, sulfate (1:1:1)
Systematic Name English
Code System Code Type Description
PUBCHEM
164888924
Created by admin on Sat Dec 16 19:28:55 GMT 2023 , Edited by admin on Sat Dec 16 19:28:55 GMT 2023
PRIMARY
CAS
2170608-33-8
Created by admin on Sat Dec 16 19:28:55 GMT 2023 , Edited by admin on Sat Dec 16 19:28:55 GMT 2023
PRIMARY
FDA UNII
CG9CW682NC
Created by admin on Sat Dec 16 19:28:55 GMT 2023 , Edited by admin on Sat Dec 16 19:28:55 GMT 2023
PRIMARY
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PARENT -> SALT/SOLVATE
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ACTIVE MOIETY