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Details

Stereochemistry ACHIRAL
Molecular Formula C6H5Hg.NO3
Molecular Weight 339.7
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PHENYLMERCURIC NITRATE

SMILES

[O-][N+]([O-])=O.[Hg+]C1=CC=CC=C1

InChI

InChIKey=PDTFCHSETJBPTR-UHFFFAOYSA-N
InChI=1S/C6H5.Hg.NO3/c1-2-4-6-5-3-1;;2-1(3)4/h1-5H;;/q;+1;-1

HIDE SMILES / InChI

Molecular Formula C6H5Hg
Molecular Weight 277.69
Charge 1
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula NO3
Molecular Weight 62.0049
Charge -1
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Phenylmercuric nitrate is classified as an antimicrobial preservative. It is bactericidal against many Gram-positive and Gram-negative species. It is used as antimicrobial preservative mainly in ophthalmic preparations. Patients who used eye drops containing the preservative, phenylmercuric nitrate for from 3 to 15 years, developed a brownish pigmentation of the anterior capsule of the pupillary area. Special studies, including electron microprobe analysis and neutron activation analysis established the presence of mercury in a lens with mercurialentis. Phenylmercuric nitrate is also an effective spermicide, although its use in vaginal contraceptives is no longer recommended.

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
Unknown

PubMed

Sample Use Guides

In Vivo Use Guide
Patch test - 0,01% aq.
Route of Administration: Topical
In Vitro Use Guide
The viable count of a plasmid-containing P. aeruginosa strain in Davis and Mingioli's minimal medium (DM) containing 10 ug/ml phenylmercuric nitrate fell by approximately 99% after 5 h.
Substance Class Chemical
Record UNII
CG8692ZN14
Record Status Validated (UNII)
Record Version