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Details

Stereochemistry ACHIRAL
Molecular Formula C32H32N2O.ClH
Molecular Weight 497.07
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of Z-160 HYDROCHLORIDE

SMILES

Cl.O=C(CC(C1=CC=CC=C1)C2=CC=CC=C2)N3CCN(CC3)C(C4=CC=CC=C4)C5=CC=CC=C5

InChI

InChIKey=ZUKCTHFFBLZBGR-UHFFFAOYSA-N
InChI=1S/C32H32N2O.ClH/c35-31(25-30(26-13-5-1-6-14-26)27-15-7-2-8-16-27)33-21-23-34(24-22-33)32(28-17-9-3-10-18-28)29-19-11-4-12-20-29;/h1-20,30,32H,21-25H2;1H

HIDE SMILES / InChI

Molecular Formula C32H32N2O
Molecular Weight 460.6093
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

NMED-160 (also known as MK-6721, NP-118809, Z-160) is a potent N-type calcium channel blockers, which has good selectivity over L-type calcium channels. Neuromed Pharmaceuticals developed this compound for the treatment of the chronic pain. However, that study was discontinued in 2007 in spite of absence of adverse events, but because drug did not demonstrate the ideal, pharmaceutical characteristics considered necessary to advance the compound further in development. Then Zalicus, Inc. was developing that drug for the treatment of chronic neuropathic pain associated with lumbosacral radiculopathy and post-herpetic neuralgia and drug was in the phase II clinical trial. Nevertheless, based on the result from trials, where Z160 did not meet the primary endpoint, Zalicus was also discontinuing the Z160 program.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
235 ng/mL
10 mg/kg single, oral
dose: 10 mg/kg
route of administration: Oral
experiment type: SINGLE
co-administered:
Z-160 plasma
Rattus norvegicus
population: UNKNOWN
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
771 ng/mL
2 mg/kg single, intravenous
dose: 2 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
Z-160 plasma
Rattus norvegicus
population: UNKNOWN
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
1136 ng × h/mL
10 mg/kg single, oral
dose: 10 mg/kg
route of administration: Oral
experiment type: SINGLE
co-administered:
Z-160 plasma
Rattus norvegicus
population: UNKNOWN
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
761 ng × h/mL
2 mg/kg single, intravenous
dose: 2 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
Z-160 plasma
Rattus norvegicus
population: UNKNOWN
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
2.1 h
10 mg/kg single, oral
dose: 10 mg/kg
route of administration: Oral
experiment type: SINGLE
co-administered:
Z-160 plasma
Rattus norvegicus
population: UNKNOWN
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
3.3 h
2 mg/kg single, intravenous
dose: 2 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
Z-160 plasma
Rattus norvegicus
population: UNKNOWN
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
Overview

Overview

OverviewOther

Other InhibitorOther SubstrateOther Inducer

Drug as perpetrator​Tox targets

Tox targets

TargetModalityActivityMetaboliteClinical evidence
PubMed

PubMed

TitleDatePubMed
Patents

Patents

Sample Use Guides

375 mg BID (twice a day) for 6 weeks
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:36:53 GMT 2023
Edited
by admin
on Fri Dec 15 16:36:53 GMT 2023
Record UNII
CD5Y84QU1P
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Z-160 HYDROCHLORIDE
Common Name English
NP-118809 HYDROCHLORIDE
Code English
1-(DIPHENYLMETHYL)-4-(3,3-DIPHENYLPROPANOYL)PIPERAZINE HYDROCHLORIDE
Systematic Name English
Code System Code Type Description
FDA UNII
CD5Y84QU1P
Created by admin on Fri Dec 15 16:36:53 GMT 2023 , Edited by admin on Fri Dec 15 16:36:53 GMT 2023
PRIMARY
CAS
41332-36-9
Created by admin on Fri Dec 15 16:36:53 GMT 2023 , Edited by admin on Fri Dec 15 16:36:53 GMT 2023
PRIMARY
PUBCHEM
119057587
Created by admin on Fri Dec 15 16:36:53 GMT 2023 , Edited by admin on Fri Dec 15 16:36:53 GMT 2023
PRIMARY
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