Z-160 HYDROCHLORIDE

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C32H32N2O.ClH
Molecular Weight	497.07
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.O=C(CC(C1=CC=CC=C1)C2=CC=CC=C2)N3CCN(CC3)C(C4=CC=CC=C4)C5=CC=CC=C5

InChI

InChIKey=ZUKCTHFFBLZBGR-UHFFFAOYSA-N

InChI=1S/C32H32N2O.ClH/c35-31(25-30(26-13-5-1-6-14-26)27-15-7-2-8-16-27)33-21-23-34(24-22-33)32(28-17-9-3-10-18-28)29-19-11-4-12-20-29;/h1-20,30,32H,21-25H2;1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C32H32N2O
Molecular Weight	460.6093
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.businesswire.com/news/home/20131111005295/en/Zalicus-Reports-Results-Phase-2-Clinical-Trials | https://www.ncbi.nlm.nih.gov/pubmed/19815411

NMED-160 (also known as MK-6721, NP-118809, Z-160) is a potent N-type calcium channel blockers, which has good selectivity over L-type calcium channels. Neuromed Pharmaceuticals developed this compound for the treatment of the chronic pain. However, that study was discontinued in 2007 in spite of absence of adverse events, but because drug did not demonstrate the ideal, pharmaceutical characteristics considered necessary to advance the compound further in development. Then Zalicus, Inc. was developing that drug for the treatment of chronic neuropathic pain associated with lumbosacral radiculopathy and post-herpetic neuralgia and drug was in the phase II clinical trial. Nevertheless, based on the result from trials, where Z160 did not meet the primary endpoint, Zalicus was also discontinuing the Z160 program.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Voltage-gated N-type calcium channel alpha-1B subunit 14 Target ID: CHEMBL4478 Sources: https://www.ncbi.nlm.nih.gov/pubmed/19815411	Blocker 555

Conditions

Condition	Modality	Highest Phase	Product
Chronic pain 9 Sources: http://www.fiercebiotech.com/biotech/press-release-neuromed-pharmaceuticals-says-to-end-development-of-pain-drug	Primary	Phase II 1147	Unknown Approved Use Unknown
Lumbosacral radiculopathy 5 Sources: https://clinicaltrials.gov/ct2/show/NCT01655849	Primary	Phase II 1147	Unknown Approved Use Unknown
Postherpetic neuralgia 13 Sources: https://clinicaltrials.gov/ct2/show/NCT01757873	Primary	Phase II 1147	Unknown Approved Use Unknown

C_max

Value	Dose	Co-administered	Analyte	Population
235 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/19815411	10 mg/kg single, oral dose: 10 mg/kg route of administration: Oral experiment type: SINGLE co-administered:		Z-160 plasma	Rattus norvegicus population: UNKNOWN age: ADULT sex: UNKNOWN food status: UNKNOWN
771 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/19815411	2 mg/kg single, intravenous dose: 2 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered:		Z-160 plasma	Rattus norvegicus population: UNKNOWN age: ADULT sex: UNKNOWN food status: UNKNOWN

AUC

Value	Dose	Co-administered	Analyte	Population
1136 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/19815411	10 mg/kg single, oral dose: 10 mg/kg route of administration: Oral experiment type: SINGLE co-administered:		Z-160 plasma	Rattus norvegicus population: UNKNOWN age: ADULT sex: UNKNOWN food status: UNKNOWN
761 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/19815411	2 mg/kg single, intravenous dose: 2 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered:		Z-160 plasma	Rattus norvegicus population: UNKNOWN age: ADULT sex: UNKNOWN food status: UNKNOWN

T_1/2

Value	Dose	Co-administered	Analyte	Population
2.1 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/19815411	10 mg/kg single, oral dose: 10 mg/kg route of administration: Oral experiment type: SINGLE co-administered:		Z-160 plasma	Rattus norvegicus population: UNKNOWN age: ADULT sex: UNKNOWN food status: UNKNOWN
3.3 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/19815411	2 mg/kg single, intravenous dose: 2 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered:		Z-160 plasma	Rattus norvegicus population: UNKNOWN age: ADULT sex: UNKNOWN food status: UNKNOWN

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
inhibitor 2252	inhibitor 2438	inhibitor 2507	inhibitor 2217

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
P-gp 1741

Drug as perpetrator

Target	Modality	Activity
CYP2D6 2546	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/bioassay/1645840#sid=363678253	no
CYP3A4 2633	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/bioassay/1645841#sid=363678253	no
P-gp 1932	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/bioassay/1346987#sid=363678253	yes [IC50 16.3601 uM]
CYP2C9 2497	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/bioassay/1645842#sid=363678253	yes [IC50 4.7724 uM]

Tox targets

Target	Modality	Activity	Metabolite	Clinical evidence
hERG 2263	inhibitor 2237 Sources: https://pubmed.ncbi.nlm.nih.gov/19815411/

PubMed

Title	Date	PubMed
Challenging the catechism of therapeutics for chronic neuropathic pain: Targeting CaV2.2 interactions with CRMP2 peptides.	2013-12-17	23831344
Structure-activity relationships of diphenylpiperazine N-type calcium channel inhibitors.	2010-02-15	20117000
Scaffold-based design and synthesis of potent N-type calcium channel blockers.	2009-11-15	19815411

Patents

Sample Use Guides

In Vivo Use Guide

375 mg BID (twice a day) for 6 weeks

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:32:37 GMT 2025` Edited by `admin` on `Mon Mar 31 18:32:37 GMT 2025`
Record UNII	CD5Y84QU1P
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

NP-118809 HYDROCHLORIDE

Preferred Name

English

Z-160 HYDROCHLORIDE

Common Name

English

1-(DIPHENYLMETHYL)-4-(3,3-DIPHENYLPROPANOYL)PIPERAZINE HYDROCHLORIDE

Systematic Name

English

Code System Code Type Description

FDA UNII

CD5Y84QU1P

Created by admin on Mon Mar 31 18:32:37 GMT 2025 , Edited by admin on Mon Mar 31 18:32:37 GMT 2025

PRIMARY

CAS

41332-36-9

Created by admin on Mon Mar 31 18:32:37 GMT 2025 , Edited by admin on Mon Mar 31 18:32:37 GMT 2025

PRIMARY

PUBCHEM

119057587

Created by admin on Mon Mar 31 18:32:37 GMT 2025 , Edited by admin on Mon Mar 31 18:32:37 GMT 2025

PRIMARY

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ACTIVE MOIETY

Details

SMILES

InChI

DescriptionSources: http://www.businesswire.com/news/home/20131111005295/en/Zalicus-Reports-Results-Phase-2-Clinical-Trials | https://www.ncbi.nlm.nih.gov/pubmed/19815411

Originator

Approval Year

Targets

Conditions

Approved Use

Approved Use

Approved Use

Cmax

AUC

T1/2

Overview

OverviewOther

Drug as perpetrator​

Tox targets

PubMed

Patents

Sample Use Guides

Description
Sources: http://www.businesswire.com/news/home/20131111005295/en/Zalicus-Reports-Results-Phase-2-Clinical-Trials | https://www.ncbi.nlm.nih.gov/pubmed/19815411

C_max

T_1/2

Drug as perpetrator