Zerlasiran Sodium

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Wed Apr 02 19:46:22 GMT 2025` Edited by `admin` on `Wed Apr 02 19:46:22 GMT 2025`
Nucleic Acid Type	siRNA
Sequence Type	COMPLETE
Record UNII	C9WT9B9PXP
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SLN-360 SODIUM SALT

Preferred Name

English

Zerlasiran Sodium

Official Name

English

ZERLASIRAN SODIUM [USAN]

Common Name

English

RNA, (Am-sp-(2?-deoxy-2?-fluoro)U-sp-Am-(2?-deoxy-2?-fluoro)A-Cm-(2?-deoxy-2?-fluoro)U-Cm-(2?-deoxy-2?-fluoro)U-Gm-(2?-deoxy-2?-fluoro)U-Cm-(2?-deoxy-2?-fluoro)C-Am-(2?-deoxy-2?-fluoro)U-Um-(2?-deoxy-2?-fluoro)A-Cm-sp-(2?-deoxy-2?-fluoro)C-sp-Gm), sodium

Common Name

English

SLN360 SODIUM SALT

Code

English

Code System Code Type Description

FDA UNII

C9WT9B9PXP

Created by admin on Wed Apr 02 19:46:22 GMT 2025 , Edited by admin on Wed Apr 02 19:46:22 GMT 2025

PRIMARY

USAN

NO-50

Created by admin on Wed Apr 02 19:46:22 GMT 2025 , Edited by admin on Wed Apr 02 19:46:22 GMT 2025

PRIMARY

CAS

3035700-09-2

Created by admin on Wed Apr 02 19:46:22 GMT 2025 , Edited by admin on Wed Apr 02 19:46:22 GMT 2025

PRIMARY

Sugar	Site Range	Site Count
2'-Fluoro-Ribose	1_7-1_9;2_2;2_4;2_6;2_8;2_10;2_12;2_14;2_16;2_18	12 / 38
2'-O-Methyl-Ribose	1_1-1_6;1_10-1_19;2_1;2_3;2_5;2_7;2_9;2_11;2_13;2_15;2_17;2_19	26 / 38

Linkage	Site Range	Site Count
Sodium Phosporothioate	1_2;1_18-1_19;2_2-2_3;2_18-2_19	7 / 36
	1_3-1_17;2_4-2_17	29 / 36

Related Record Type Details


					FBX7PTD863

Zerlasiran

PARENT -> SALT/SOLVATE

Amount:

Related Record Type Details


					FBX7PTD863

Zerlasiran

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOTIDE SUBSTITUTION	[1_1]	5'-TERMINUS			Zerlasiran 5'-modification	VTF9MMJ8CN