Rats: Manganese oxalate, dihydrate was administered daily by oral gavage to SPF-bred Wistar rats of both sexes at dose levels of 100, 300 and 1000 mg/kg body weight/day for a period of 28 days. Oral administration of Manganese oxalate, dihydrate to Wistar rats at dosages of 100, 300, and 1000 mg/kg body weight/day (in terms of Manganese Oxalate, anhydrous form, which is equivalent to 125.2, 375.6 and 1252 mg/kg body weight/day of the test item), for 28 days resulted in no deaths of toxicological relevance, no clinical signs during daily or weekly observations, no clinical signs during the functional observational battery at week 4, no effects on fore- or hindlimb grip strength or on locomotor activity, and no effects on mean food consumption.

Unknown