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Details

Stereochemistry ACHIRAL
Molecular Formula Ca.O
Molecular Weight 56.077
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LIME (CALCIUM OXIDE)

SMILES

[O--].[Ca++]

InChI

InChIKey=BRPQOXSCLDDYGP-UHFFFAOYSA-N
InChI=1S/Ca.O/q+2;-2

HIDE SMILES / InChI

Molecular Formula HO
Molecular Weight 17.0073
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Ca
Molecular Weight 40.078
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including https://www.drugs.com/international/olaflur.html | https://www.ncbi.nlm.nih.gov/pubmed/15528912 | https://clinicaltrials.gov/ct2/show/record/NCT00268138 | https://www.old.health.gov.il/units/pharmacy/trufot/alonim/4872.pdf

Olaflur (amine fluoride 297, trade name elmex gel) is a fluoride-containing substance that is an ingredient of toothpastes and solutions for the prevention of dental caries. Especially in combination with dectaflur, it is also used in the form of gels for the treatment of early stages of caries, sensitive teeth, and by dentists for the refluoridation of damaged tooth enamel. Olaflur is a salt consisting of an alkyl ammonium cation and fluoride as the counterion. With a long lipophilic hydrocarbon chain, the cation has surfactant properties. It forms a film layer on the surface of teeth, which facilitates incorporation of fluoride into the enamel. The top layers of the enamel's primary mineral, hydroxylapatite, are converted into the more robust fluorapatite. The fluoridation reaches only a depth of a few nanometres, which has raised doubts whether the mechanism really relies on the formation of fluorapatite.

CNS Activity

Originator

Sources: Helvetica Odontologica Acta (1962), 6, (1), 15-20.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
elmex

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Allergic contact cheilitis caused by olaflur in toothpaste.
2017-01
Cytotoxicity of organic surface coating agents used for nanoparticles synthesis and stability.
2015-06
Oleylamine as a beneficial agent for the synthesis of CoFe₂O₄ nanoparticles with potential biomedical uses.
2014-05-07
Sensitivity of human dental pulp cells to eighteen chemical agents used for endodontic treatments in dentistry.
2013-01
Successful extracorporeal life support after potentially fatal pulmonary oedema caused by inhalation of nitric and hydrofluoric acid fumes.
2007-10
Epidemiology of 377 patients with chemical burns in Guangdong province.
2004-09
An improved method for emergent decontamination of ocular and dermal hydrofluoric acid splashes.
2004-08
Patents

Patents

Sample Use Guides

toxicity in mice: LD50 = 888 mg/kg
Route of Administration: Intraperitoneal
Cytotoxicity study: it was explored the cytotoxicity of the coating agent, Oleylamine in two cell lines, human epidermal keratinocyte (HaCaT) and lung fibroblast (CRL-1490) cells, at surface coating agent concentrations of 3, 10, 30, and 100 μM. Two exposure time points, 2 h, and 24 h were employed for the study. Oleylamine, is highly toxic, leading to almost 100% cell death.
Substance Class Chemical
Created
by admin
on Mon Mar 31 18:31:31 GMT 2025
Edited
by admin
on Mon Mar 31 18:31:31 GMT 2025
Record UNII
C7X2M0VVNH
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CALCIUM OXIDE
FCC   INCI   MART.   MI   WHO-DD  
INCI  
Preferred Name English
LIME (CALCIUM OXIDE)
II  
Common Name English
LIME
HSDB   USP  
Common Name English
CALCIUM OXIDE [MART.]
Common Name English
LIME (CAO)
Common Name English
Calcium oxide [WHO-DD]
Common Name English
CALCIUM OXIDE [FCC]
Common Name English
INS NO.529
Code English
LIME (CHEMICAL)
Common Name English
LIME [HSDB]
Common Name English
LIME [USP MONOGRAPH]
Common Name English
BURNT LIME
Common Name English
E-529
Code English
INS-529
Code English
LIME (CALCIUM OXIDE) [II]
Common Name English
CALCIUM OXIDE [JAN]
Common Name English
CALX
Common Name English
CALCIUM OXIDE [MI]
Common Name English
QUICKLIME
Common Name English
Classification Tree Code System Code
CFR 21 CFR 184.1210
Created by admin on Mon Mar 31 18:31:31 GMT 2025 , Edited by admin on Mon Mar 31 18:31:31 GMT 2025
WHO-VATC QP53AX18
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DSLD 260 (Number of products:101)
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NCI_THESAURUS C42634
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EPA PESTICIDE CODE 75604
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CODEX ALIMENTARIUS (GSFA) INS-529
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JECFA EVALUATION INS-529
Created by admin on Mon Mar 31 18:31:31 GMT 2025 , Edited by admin on Mon Mar 31 18:31:31 GMT 2025
Code System Code Type Description
MESH
C016538
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PRIMARY
WIKIPEDIA
CALCIUM OXIDE
Created by admin on Mon Mar 31 18:31:31 GMT 2025 , Edited by admin on Mon Mar 31 18:31:31 GMT 2025
PRIMARY
EPA CompTox
DTXSID5029631
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PRIMARY
CHEBI
31344
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PRIMARY
NCI_THESAURUS
C82641
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PRIMARY
MERCK INDEX
m2958
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PRIMARY Merck Index
PUBCHEM
6850728
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PRIMARY
HSDB
1615
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PRIMARY
CHEBI
51486
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PRIMARY
SMS_ID
100000092621
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PRIMARY
DAILYMED
C7X2M0VVNH
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PRIMARY
DRUG BANK
DB15648
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PRIMARY
CAS
1305-78-8
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PRIMARY
ECHA (EC/EINECS)
215-138-9
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PRIMARY
FDA UNII
C7X2M0VVNH
Created by admin on Mon Mar 31 18:31:31 GMT 2025 , Edited by admin on Mon Mar 31 18:31:31 GMT 2025
PRIMARY
ChEMBL
CHEMBL2104397
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PRIMARY
EVMPD
SUB13189MIG
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PRIMARY
EVMPD
SUB29992
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PRIMARY
RXCUI
28728
Created by admin on Mon Mar 31 18:31:31 GMT 2025 , Edited by admin on Mon Mar 31 18:31:31 GMT 2025
PRIMARY RxNorm