TALSUPRAM

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	RACEMIC
Molecular Formula	C20H25NS
Molecular Weight	311.484
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of TALSUPRAM

Structure Search

SMILES

CNCCCC1(SC(C)(C)C2=CC=CC=C12)C3=CC=CC=C3

InChI

InChIKey=FKHYYOUFMJBLAF-UHFFFAOYSA-N

InChI=1S/C20H25NS/c1-19(2)17-12-7-8-13-18(17)20(22-19,14-9-15-21-3)16-10-5-4-6-11-16/h4-8,10-13,21H,9,14-15H2,1-3H3

HIDE SMILES / InChI

Molecular Formula	C20H25NS
Molecular Weight	311.484
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/16322935 | Fillion G., Briley M., New Concepts in Depression, retrieved from: https://books.google.ru/books?id=pDRdDwAAQBAJ&pg=PA205&lpg=PA205&dq=TALSUPRAM+depression&source=bl&ots=-LzpLlJNVi&sig=ACfU3U2NjQNkXOPDi-BRoWiTmY-VVV62Og&hl=ru&sa=X&ved=2ahUKEwjxyMiL0prjAhXq0aYKHVXxDR8Q6AEwB3oECAkQAQ#v=onepage&q=TALSUPRAM%20depression&f=false

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
Norepinephrine transporter 191 Target ID: CHEMBL222 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2999402	Inhibitor 8297		0.79 nM [IC50]
Dopamine transporter 180 Target ID: CHEMBL238 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2999402	Inhibitor 8297		9300.0 nM [IC50]
Serotonin transporter 178 Target ID: CHEMBL228 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2999402	Inhibitor 8297		850.0 nM [IC50]
Norepinephrine transporter 191 Target ID: CHEMBL222 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2999402	Inhibitor 8297		0.79 nM [IC50]

PubMed

PubMed

Title	Date	PubMed

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:34:28 GMT 2023` Edited by `admin` on `Fri Dec 15 18:34:28 GMT 2023`
Record UNII	C6Z73MW6CR
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TALSUPRAM

Official Name

English

talsupram [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C265

Created by admin on Fri Dec 15 18:34:28 GMT 2023 , Edited by admin on Fri Dec 15 18:34:28 GMT 2023

Code System Code Type Description

MESH

C001750

Created by admin on Fri Dec 15 18:34:28 GMT 2023 , Edited by admin on Fri Dec 15 18:34:28 GMT 2023

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FDA UNII

C6Z73MW6CR

Created by admin on Fri Dec 15 18:34:28 GMT 2023 , Edited by admin on Fri Dec 15 18:34:28 GMT 2023

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WIKIPEDIA

Talsupram

Created by admin on Fri Dec 15 18:34:28 GMT 2023 , Edited by admin on Fri Dec 15 18:34:28 GMT 2023

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ChEMBL

CHEMBL52247

Created by admin on Fri Dec 15 18:34:28 GMT 2023 , Edited by admin on Fri Dec 15 18:34:28 GMT 2023

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DRUG BANK

DB09191

Created by admin on Fri Dec 15 18:34:28 GMT 2023 , Edited by admin on Fri Dec 15 18:34:28 GMT 2023

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EPA CompTox

DTXSID50864992

Created by admin on Fri Dec 15 18:34:28 GMT 2023 , Edited by admin on Fri Dec 15 18:34:28 GMT 2023

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SMS_ID

100000083209

Created by admin on Fri Dec 15 18:34:28 GMT 2023 , Edited by admin on Fri Dec 15 18:34:28 GMT 2023

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PUBCHEM

33014

Created by admin on Fri Dec 15 18:34:28 GMT 2023 , Edited by admin on Fri Dec 15 18:34:28 GMT 2023

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EVMPD

SUB10815MIG

Created by admin on Fri Dec 15 18:34:28 GMT 2023 , Edited by admin on Fri Dec 15 18:34:28 GMT 2023

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INN

3076

Created by admin on Fri Dec 15 18:34:28 GMT 2023 , Edited by admin on Fri Dec 15 18:34:28 GMT 2023

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CAS

21489-20-3

Created by admin on Fri Dec 15 18:34:28 GMT 2023 , Edited by admin on Fri Dec 15 18:34:28 GMT 2023

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NCI_THESAURUS

C75180

Created by admin on Fri Dec 15 18:34:28 GMT 2023 , Edited by admin on Fri Dec 15 18:34:28 GMT 2023

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Related Record Type Details


					C6Z73MW6CR

TALSUPRAM

ACTIVE MOIETY