Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C2H3NO |
| Molecular Weight | 57.0513 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN=C=O
InChI
InChIKey=HAMGRBXTJNITHG-UHFFFAOYSA-N
InChI=1S/C2H3NO/c1-3-2-4/h1H3
| Molecular Formula | C2H3NO |
| Molecular Weight | 57.0513 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Optical Activity | NONE |
Methyl isocyanate (MIC) is a noxious industrial chemical used extensively in the production of carbamate pesticides. This compound is a respiratory toxicant. Recently published studies have shown that methyl isocyanate can lead to epigenetic alterations due to its strong binding with DNA methyltransferase 1 (DNMT1) which is responsible for maintenance of normal methylation, cell growth and survival in mammals.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Non-heme dioxygenase catalyzes atypical oxidations of 6,7-bicyclic systems to form the 6,6-quinolone core of viridicatin-type fungal alkaloids. | 2014-11-17 |
|
| Cell cycle deregulation by methyl isocyanate: Implications in liver carcinogenesis. | 2014-03 |
|
| Molecular mechanisms of isocyanate induced oncogenic transformation in ovarian epithelial cells. | 2010-11 |
|
| 2,2-Dimethyl-1,3-benzodioxol-4-yl N-methyl-carbamate. | 2010-09-18 |
|
| 25 years after the Bhopal gas tragedy. | 2010-09-16 |
|
| [The Bhopal tragedy 25 (10+15) years after]. | 2010-09-11 |
|
| Effects of exposure of parents to toxic gases in Bhopal on the offspring. | 2010-08 |
|
| Aromatic substitution reactions between ionized benzene derivatives and neutral methyl isocyanide. | 2010-07-15 |
|
| Bhopal. India launches new probe of cyanide disaster. | 2010-07-02 |
|
| Triage, monitoring, and treatment of mass casualty events involving chemical, biological, radiological, or nuclear agents. | 2010-07 |
|
| Sensory detection and responses to toxic gases: mechanisms, health effects, and countermeasures. | 2010-07 |
|
| Adsorption efficiency of respirator filter cartridges for isocyanates. | 2010-06 |
|
| Regulation of isocyanate-induced apoptosis, oxidative stress, and inflammation in cultured human neutrophils: isocyanate-induced neutrophils apoptosis. | 2010-06 |
|
| A new general pathway for synthesis of reference compounds of N-terminal valine-isocyanate adducts. | 2010-03-15 |
|
| Different experimental approaches in modelling cataractogenesis: An overview of selenite-induced nuclear cataract in rats. | 2010-03 |
|
| Investigating genetic outcomes following 1984 Toxic Union Carbide disaster in India: epidemiological challenges. | 2010 |
|
| Molecular characterization of isocyanate-induced male germ-line genomic instability. | 2010 |
|
| Status of inflammatory biomarkers in the population that survived the Bhopal gas tragedy: a study after two decades. | 2010 |
|
| The interaction of zinc(II) and hydroxamic acids and a metal-triggered Lossen rearrangement. | 2009-12-14 |
|
| A submarine journey: the pyrrole-imidazole alkaloids. | 2009-11-27 |
|
| Correlation of aberrant expression of p53, Rad50, and cyclin-E proteins with microsatellite instability in gallbladder adenocarcinomas. | 2009-10-06 |
|
| Clinical activity of laromustine (Onrigin™) in hematologic malignancies. | 2009-10 |
|
| An in vitro evaluation of the victim and perpetrator potential of the anticancer agent laromustine (VNP40101M), based on reaction phenotyping and inhibition and induction of cytochrome P450 enzymes. | 2009-09 |
|
| Mitochondrial oxidative stress elicits chromosomal instability after exposure to isocyanates in human kidney epithelial cells. | 2009-08 |
|
| Induction of genomic instability in cultured human colon epithelial cells following exposure to isocyanates. | 2009-06 |
|
| Respiratory symptoms and lung function in foundry workers exposed to low molecular weight isocyanates. | 2009-06 |
|
| Analysis of cellular response to isocyanate using N-succinimidyl N-methylcarbamate exposure in cultured mammalian cells. | 2009-05 |
|
| In utero exposure to methyl isocyanate in the Bhopal gas disaster: evidence of persisting hyperactivation of immune system two decades later. | 2009-04 |
|
| Identification and fragmentation pathways of caffeine metabolites in urine samples via liquid chromatography with positive electrospray ionization coupled to a hybrid quadrupole linear ion trap (LTQ) and Fourier transform ion cyclotron resonance mass spectrometry and tandem mass spectrometry. | 2009-04 |
|
| Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases. | 2009-04 |
|
| Inflammatory response to isocyanates and onset of genomic instability in cultured human lung fibroblasts. | 2009-02-10 |
|
| Laromustine, a sulfonyl hydrolyzing alkylating prodrug for cancer therapy. | 2009-01 |
|
| Bhopal Gas Tragedy: review of clinical and experimental findings after 25 years. | 2009 |
|
| Rats repeatedly exposed to toluene diisocyanate exhibit immune reactivity against methyl isocyanate-protein conjugates. | 2009 |
|
| Isocyanates induces DNA damage, apoptosis, oxidative stress, and inflammation in cultured human lymphocytes. | 2008-12-30 |
|
| 2-(2-Methyl-5-nitro-1H-imidazol-1-yl)ethyl N-methyl-carbamate. | 2008-12-13 |
|
| A case of isocyanate-induced asthma possibly complicated by food allergy after peanut consumption: a case report. | 2008-11-26 |
|
| Validation of transferability of DBA derivatization and LC-MS/MS determination method for isocyanates via an interlaboratory comparison. | 2008-11 |
|
| Initial testing of VNP40101M (Cloretazine) by the pediatric preclinical testing program. | 2008-09 |
|
| Aftermath of the Bhopal accident. | 2008-06-07 |
|
| Representation and re-presentation in litigation science. | 2008-01 |
|
| Overseas experience in global health: travels to Bhopal, India, 20 years after the Union Carbide disaster. | 2008-01 |
|
| Building capacity to address emerging problems in developing countries: intentional self-poisoning and pesticides. | 2008 |
|
| Evaluation and application of the RD50 for determining acceptable exposure levels of airborne sensory irritants for the general public. | 2007-11 |
|
| Abstracts of papers presented at the 2007 pittsburgh conference. | 2007 |
|
| Binding of [1-14C]methyl isocyanate to erythrocyte membrane proteins. | 1996-03-01 |
|
| Chronic lung inflammation in victims of toxic gas leak at Bhopal. | 1995-02 |
|
| Influence of methylamine and N,N'-dimethylurea, the hydrolysis products of methyl isocyanate, on its systemic toxicity. | 1993-01-01 |
|
| The antibody response to methyl isocyanate: experimental and clinical findings. | 1987-06 |
|
| Use of hexyl isocyanate antigen to detect antibodies to hexamethylene diisocyanate (HDI) in sensitized guinea pigs and in a sensitized worker. | 1982-05-01 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 18:40:26 GMT 2025
by
admin
on
Mon Mar 31 18:40:26 GMT 2025
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| Record UNII |
C588JJ4BV9
|
| Record Status |
Validated (UNII)
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| Record Version |
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64323
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