Ryuvidine

CC1=NC2=C(S1)C(=O)C=C(NC3=CC=C(C)C=C3)C2=O

InChIKey=HFPLHASLIOXVGS-UHFFFAOYSA-N

InChI=1S/C15H12N2O2S/c1-8-3-5-10(6-4-8)17-11-7-12(18)15-13(14(11)19)16-9(2)20-15/h3-7,17H,1-2H3

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Condition	Potency
Cyclin-dependent kinase 4 22 Target ID: CHEMBL331 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10743948	Inhibitor 8297		6.0 nM [IC50]
N-lysine methyltransferase SETD8 1 Target ID: CHEMBL1795176 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25137013	Inhibitor 8297		0.5 µM [IC50]

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:31:28 UTC 2023` Edited by `admin` on `Fri Dec 15 17:31:28 UTC 2023`
Record UNII	C4QER4DF5C
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

Ryuvidine

Common Name

English

4,7-Benzothiazoledione, 2-methyl-5-[(4-methylphenyl)amino]-

Systematic Name

English

Cdk4 inhibitor III

Common Name

English

2-Methyl-5-[(4-methylphenyl)amino]-4,7-benzothiazoledione

Systematic Name

English

Code System Code Type Description

CAS

265312-55-8

Created by admin on Fri Dec 15 17:31:28 UTC 2023 , Edited by admin on Fri Dec 15 17:31:28 UTC 2023

PRIMARY

PUBCHEM

481747

Created by admin on Fri Dec 15 17:31:28 UTC 2023 , Edited by admin on Fri Dec 15 17:31:28 UTC 2023

PRIMARY

FDA UNII

C4QER4DF5C

Created by admin on Fri Dec 15 17:31:28 UTC 2023 , Edited by admin on Fri Dec 15 17:31:28 UTC 2023

PRIMARY

Related Record Type Details


					D6NY137WFQ

TARGET -> INHIBITOR